Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2002 Jul 4;418(6893):50-6.
doi: 10.1038/nature00900. Epub 2002 Jun 20.

Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease

Jong-Hoon Kim  1 , Jonathan M Auerbach, José A Rodríguez-Gómez, Iván Velasco, Denise Gavin, Nadya Lumelsky, Sang-Hun Lee, John Nguyen, Rosario Sánchez-Pernaute, Krys Bankiewicz, Ron McKay
Affiliations

Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease

Jong-Hoon Kim et al. Nature. .

Abstract

Parkinson's disease is a widespread condition caused by the loss of midbrain neurons that synthesize the neurotransmitter dopamine. Cells derived from the fetal midbrain can modify the course of the disease, but they are an inadequate source of dopamine-synthesizing neurons because their ability to generate these neurons is unstable. In contrast, embryonic stem (ES) cells proliferate extensively and can generate dopamine neurons. If ES cells are to become the basis for cell therapies, we must develop methods of enriching for the cell of interest and demonstrate that these cells show functions that will assist in treating the disease. Here we show that a highly enriched population of midbrain neural stem cells can be derived from mouse ES cells. The dopamine neurons generated by these stem cells show electrophysiological and behavioural properties expected of neurons from the midbrain. Our results encourage the use of ES cells in cell-replacement therapy for Parkinson's disease.

PubMed Disclaimer

Comment in

  • A human stem cell project?
    [No authors listed] [No authors listed] Nature. 2002 Jul 4;418(6893):1. doi: 10.1038/418001a. Nature. 2002. PMID: 12097865 No abstract available.
  • Stem-cell competition.
    Orkin SH, Morrison SJ. Orkin SH, et al. Nature. 2002 Jul 4;418(6893):25-7. doi: 10.1038/418025a. Nature. 2002. PMID: 12097889 No abstract available.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Publication types

MeSH terms

  NODES
Project 1
twitter 2