Calreticulin in cardiac development and pathology
- PMID: 12445456
- DOI: 10.1016/s1570-9639(02)00441-7
Calreticulin in cardiac development and pathology
Abstract
Calreticulin is a Ca(2+) binding/storage chaperone resident in the lumen of endoplasmic reticulum (ER). The protein is an important component of the calreticulin/calnexin cycle and the quality control pathways in the ER. In mice, calreticulin deficiency is lethal due to impaired cardiac development. This is not surprising because the protein is expressed at high level at early stages of cardiac development. Overexpression of the protein in developing and postnatal heart leads to bradycardia, complete heart block and sudden death. Recent studies on calreticulin-deficient and transgenic mice revealed that the protein is a key upstream regulator of calcineurin-dependent pathways during cardiac development. Calreticulin and ER may play important role in cardiac development and postnatal pathologies.
Similar articles
-
Calreticulin in the heart.Mol Cell Biochem. 2004 Aug;263(1-2):137-42. Mol Cell Biochem. 2004. PMID: 15524174 Review.
-
Assembling pieces of the cardiac puzzle; calreticulin and calcium-dependent pathways in cardiac development, health, and disease.Trends Cardiovasc Med. 2006 Apr;16(3):65-9. doi: 10.1016/j.tcm.2006.01.004. Trends Cardiovasc Med. 2006. PMID: 16546685 Review.
-
Calreticulin is an upstream regulator of calcineurin.Biochem Biophys Res Commun. 2003 Nov 28;311(4):1173-9. doi: 10.1016/j.bbrc.2003.08.040. Biochem Biophys Res Commun. 2003. PMID: 14623303 Review.
-
Calreticulin in the heart.Mol Cell Biochem. 2004 Aug;263(1):137-42. doi: 10.1023/B:MCBI.0000041855.10149.5f. Mol Cell Biochem. 2004. PMID: 27520672
-
Complete heart block and sudden death in mice overexpressing calreticulin.J Clin Invest. 2001 May;107(10):1245-53. doi: 10.1172/JCI12412. J Clin Invest. 2001. PMID: 11375414 Free PMC article.
Cited by
-
Differentially expressed genes in embryonic cardiac tissues of mice lacking Folr1 gene activity.BMC Dev Biol. 2007 Nov 20;7:128. doi: 10.1186/1471-213X-7-128. BMC Dev Biol. 2007. PMID: 18028541 Free PMC article.
-
NKX3.1 is a direct TAL1 _target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia.J Exp Med. 2010 Sep 27;207(10):2141-56. doi: 10.1084/jem.20100745. Epub 2010 Sep 20. J Exp Med. 2010. PMID: 20855495 Free PMC article.
-
Anti-erbB2 treatment induces cardiotoxicity by interfering with cell survival pathways.Breast Cancer Res. 2006;8(4):R35. doi: 10.1186/bcr1523. Breast Cancer Res. 2006. PMID: 16839426 Free PMC article.
-
[Rictor regulates mitochondrial calcium signaling in mouse embryo stem cell-derived cardiomyocytes].Zhejiang Da Xue Xue Bao Yi Xue Ban. 2019 May 25;48(1):65-74. doi: 10.3785/j.issn.1008-9292.2019.02.11. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2019. PMID: 31102360 Free PMC article. Chinese.
-
Mitochondria and Ca(2+) signaling: old guests, new functions.Pflugers Arch. 2007 Dec;455(3):375-96. doi: 10.1007/s00424-007-0296-1. Epub 2007 Jul 5. Pflugers Arch. 2007. PMID: 17611770 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
Miscellaneous
