doi: 10.1126/science.1079368.
Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide
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- PMID: 12574632
- DOI: 10.1126/science.1079368
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Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide
Science.
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Abstract
Nitric oxide was found to trigger mitochondrial biogenesis in cells as diverse as brown adipocytes and 3T3-L1, U937, and HeLa cells. This effect of nitric oxide was dependent on guanosine 3',5'-monophosphate (cGMP) and was mediated by the induction of peroxisome proliferator-activated receptor gamma coactivator 1alpha, a master regulator of mitochondrial biogenesis. Moreover, the mitochondrial biogenesis induced by exposure to cold was markedly reduced in brown adipose tissue of endothelial nitric oxide synthase null-mutant (eNOS-/-) mice, which had a reduced metabolic rate and accelerated weight gain as compared to wild-type mice. Thus, a nitric oxide-cGMP-dependent pathway controls mitochondrial biogenesis and body energy balance.
Comment in
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Cell biology. NO says yes to mitochondria.Science. 2003 Feb 7;299(5608):838-9. doi: 10.1126/science.1082028. Science. 2003. PMID: 12574611 No abstract available.
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Mitochondrial biogenesis: which part of "NO" do we understand?Bioessays. 2003 Jun;25(6):538-41. doi: 10.1002/bies.10298. Bioessays. 2003. PMID: 12766943 Review.
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