In vivo magnetic resonance imaging of mesenchymal stem cells in myocardial infarction
- PMID: 12732608
- DOI: 10.1161/01.CIR.0000070931.62772.4E
In vivo magnetic resonance imaging of mesenchymal stem cells in myocardial infarction
Abstract
Background: We investigated the potential of magnetic resonance imaging (MRI) to track magnetically labeled mesenchymal stem cells (MR-MSCs) in a swine myocardial infarction (MI) model.
Methods and results: Adult farm pigs (n=5) were subjected to closed-chest experimental MI. MR-MSCs (2.8 to 16x107 cells) were injected intramyocardially under x-ray fluoroscopy. MRIs were obtained on a 1.5T MR scanner to demonstrate the location of the MR-MSCs and were correlated with histology. Contrast-enhanced MRI demonstrated successful injection in the infarct and serial MSC tracking was demonstrated in two animals.
Conclusions: MRI tracking of MSCs is feasible and represents a preferred method for studying the engraftment of MSCs in MI.
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