Review
doi: 10.1038/nri1088.
What does it take to make a natural killer?
Affiliations
- PMID: 12766763
- DOI: 10.1038/nri1088
Item in Clipboard
Review
What does it take to make a natural killer?
Nat Rev Immunol.
2003 May.
Abstract
We know how B and T cells develop, what they 'see' and the receptors they 'see with'. By contrast, and despite an unprecedented increase in the number of receptors and ligands known to regulate the activity of natural killer (NK) cells, we still have many questions regarding how these cells develop. Nevertheless, we are beginning to understand the transcriptional programmes of NK-cell maturation and the role of the effector functions of NK cells in the regulation of immune responses. An improved knowledge of NK-cell development in mice and humans might be useful to harness the power of these natural killers in the clinic to fight autoimmune diseases, infection and cancer.
Similar articles
-
Osteopontin promotes the development of natural killer cells from hematopoietic stem cells.Stem Cells. 2008 Aug;26(8):2114-23. doi: 10.1634/stemcells.2008-0370. Epub 2008 Jun 5. Stem Cells. 2008. PMID: 18535152
-
TOX regulates the differentiation of human natural killer cells from hematopoietic stem cells in vitro.Immunol Lett. 2011 Apr 30;136(1):29-36. doi: 10.1016/j.imlet.2010.11.008. Epub 2010 Nov 30. Immunol Lett. 2011. PMID: 21126536
-
Immune functions encoded by the natural killer gene complex.Nat Rev Immunol. 2003 Apr;3(4):304-16. doi: 10.1038/nri1055. Nat Rev Immunol. 2003. PMID: 12669021 Review.
-
Expanded donor natural killer cell and IL-2, IL-15 treatment efficacy in allogeneic hematopoietic stem cell transplantation.Eur J Haematol. 2008 Sep;81(3):226-35. doi: 10.1111/j.1600-0609.2008.01108.x. Epub 2008 Jun 28. Eur J Haematol. 2008. PMID: 18573173
-
Different checkpoints in human NK-cell activation.Trends Immunol. 2004 Dec;25(12):670-6. doi: 10.1016/j.it.2004.09.008. Trends Immunol. 2004. PMID: 15530838 Review.
Cited by
-
On the Way to Become a Natural Killer Cell.Front Immunol. 2019 Aug 2;10:1812. doi: 10.3389/fimmu.2019.01812. eCollection 2019. Front Immunol. 2019. PMID: 31428098 Free PMC article. Review.
-
Epigenetic Mechanisms Dictating Eradication of Cancer by Natural Killer Cells.Trends Cancer. 2018 Aug;4(8):553-566. doi: 10.1016/j.trecan.2018.06.004. Epub 2018 Jul 3. Trends Cancer. 2018. PMID: 30064663 Free PMC article. Review.
-
Functional convalescent plasma antibodies and pre-infusion titers shape the early severe COVID-19 immune response.Nat Commun. 2021 Nov 25;12(1):6853. doi: 10.1038/s41467-021-27201-y. Nat Commun. 2021. PMID: 34824251 Free PMC article.
-
Tolerance of NK cells encountering their viral ligand during development.J Exp Med. 2008 Aug 4;205(8):1819-28. doi: 10.1084/jem.20072448. Epub 2008 Jul 7. J Exp Med. 2008. PMID: 18606858 Free PMC article.
-
Natural killer cell responses to viral infection.J Innate Immun. 2011;3(3):274-9. doi: 10.1159/000324176. Epub 2011 Mar 12. J Innate Immun. 2011. PMID: 21411975 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
