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Review
. 2004 Jan 23;116(2):337-50.
doi: 10.1016/s0092-8674(03)01081-x.

Obesity wars: molecular progress confronts an expanding epidemic

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Free article
Review

Obesity wars: molecular progress confronts an expanding epidemic

Jeffrey S Flier. Cell. .
Free article

Abstract

The worldwide prevalence of obesity is increasing at an alarming rate, with major adverse consequences for human health. This "obesity epidemic" is paralleled by a rapid and substantive increase in our understanding of molecular pathways and physiologic systems underlying the regulation of energy balance. While efforts to address the environmental factors that are responsible for the recent "epidemic" must continue, new molecular and physiologic insights into this system offer exciting possibilities for future development of successful therapies.

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