Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2004 Jul 16;305(5682):390-2.
doi: 10.1126/science.1099196. Epub 2004 Jun 17.

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

Haim Y Cohen  1 , Christine Miller, Kevin J Bitterman, Nathan R Wall, Brian Hekking, Benedikt Kessler, Konrad T Howitz, Myriam Gorospe, Rafael de Cabo, David A Sinclair
Affiliations

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

Haim Y Cohen et al. Science. .

Abstract

A major cause of aging is thought to result from the cumulative effects of cell loss over time. In yeast, caloric restriction (CR) delays aging by activating the Sir2 deacetylase. Here we show that expression of mammalian Sir2 (SIRT1) is induced in CR rats as well as in human cells that are treated with serum from these animals. Insulin and insulin-like growth factor 1 (IGF-1) attenuated this response. SIRT1 deacetylates the DNA repair factor Ku70, causing it to sequester the proapoptotic factor Bax away from mitochondria, thereby inhibiting stress-induced apoptotic cell death. Thus, CR could extend life-span by inducing SIRT1 expression and promoting the long-term survival of irreplaceable cells.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Publication types

MeSH terms

  NODES
twitter 2