Review
doi: 10.1016/j.tcb.2004.07.013.
Checkpoints in ER-associated degradation: excuse me, which way to the proteasome?
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- PMID: 15350974
- DOI: 10.1016/j.tcb.2004.07.013
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Review
Checkpoints in ER-associated degradation: excuse me, which way to the proteasome?
Trends Cell Biol.
2004 Sep.
Abstract
The failure of secreted proteins to fold results in their retrotranslocation from the endoplasmic reticulum (ER) and degradation by the proteasome in a process called "ER-associated degradation" (ERAD). Two recent studies indicate that ERAD substrates are _targeted to different pathways depending on the topology of the substrate and the subcellular location of the misfolded domain.
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