Review
doi: 10.2174/1389557043403459.
Intervention of hepatic glucose production. Small molecule regulators of potential _targets for Type 2 diabetes therapy
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- PMID: 15544551
- DOI: 10.2174/1389557043403459
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Review
Intervention of hepatic glucose production. Small molecule regulators of potential _targets for Type 2 diabetes therapy
Mini Rev Med Chem.
2004 Oct.
Abstract
Excessive hepatic glucose production is thought to be a major contributor to the type 2 diabetic state. Drug discovery efforts have yielded small synthetic inhibitors for gluconeogenic and glycogenic regulators of this pathway. The most advanced _targets are outlined in this mini-review and include: the glucocorticoid receptor, 11 beta-hydroxysteroid dehydrogenase type 1, fructose 1,6-bisphosphatase, the glucagon receptor, glycogen phosphorylase, glycogen synthase kinase-3, and glucose-6-phosphatase.
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