The role of B cells and accessory cells in the neonatal response to TI-2 antigens

doi:10.1385/IR:31:1:25

Review

. 2005;31(1):25-36.

doi: 10.1385/IR:31:1:25.

The role of B cells and accessory cells in the neonatal response to TI-2 antigens

Cheri D Landers¹, R Lakshman Chelvarajan, Subbarao Bondada

Affiliations

Affiliation

¹ Department of Pediatrics, Division of Pediatric Critical Care, Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA. cdland2@uky.edu

PMID: 15591620
DOI: 10.1385/IR:31:1:25

Review

The role of B cells and accessory cells in the neonatal response to TI-2 antigens

Cheri D Landers et al. Immunol Res. 2005.

. 2005;31(1):25-36.

doi: 10.1385/IR:31:1:25.

Authors

Cheri D Landers¹, R Lakshman Chelvarajan, Subbarao Bondada

Affiliation

¹ Department of Pediatrics, Division of Pediatric Critical Care, Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA. cdland2@uky.edu

PMID: 15591620
DOI: 10.1385/IR:31:1:25

Abstract

The neonate has an increased susceptibility to infection, in part owing to an inability to produce antibody to thymus-independent antigens such as bacterial polysaccharides (PS). This poor response to PS antigens is likely owing to multiple factors. Neonatal B cells are of an immature phenotype, as evidenced by cell-surface marker characteristics and increased susceptibility to tolerance induction. The spleen of the neonate has a different cellular composition, which is most prominent in the marginal zone. Neonatal accessory cells such as macrophages and dendritic cells (DCs) appear to produce less stimulatory cytokines and an overabundance of inhibitory cytokines. This review examines the current data supporting the role of B cells and accessory cells in the neonatal unresponsiveness to PS antigens.

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References

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[1] J Immunol. 1997 Mar 15;158(6):2731-5 - PubMed

[2] J Immunol. 1997 Mar 15;158(6):2731-5 - PubMed

[3] Cell Immunol. 1980 Sep 15;55(1):191-200 - PubMed

[4] Cell Immunol. 1980 Sep 15;55(1):191-200 - PubMed

[5] J Immunol. 1988 May 1;140(9):2925-30 - PubMed

[6] J Immunol. 1988 May 1;140(9):2925-30 - PubMed

[7] J Infect Dis. 1992 Jun;165 Suppl 1:S44-8 - PubMed

[8] J Infect Dis. 1992 Jun;165 Suppl 1:S44-8 - PubMed

[9] Immunol Rev. 1977;37:89-104 - PubMed

[10] Immunol Rev. 1977;37:89-104 - PubMed

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The role of B cells and accessory cells in the neonatal response to TI-2 antigens

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The role of B cells and accessory cells in the neonatal response to TI-2 antigens

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