Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2005 Jan 1;33(Database issue):D537-43.
doi: 10.1093/nar/gki017.

HAGR: the Human Ageing Genomic Resources

João Pedro de Magalhães  1 , Joana Costa, Olivier Toussaint
Affiliations

HAGR: the Human Ageing Genomic Resources

João Pedro de Magalhães et al. Nucleic Acids Res. .

Abstract

The Human Ageing Genomic Resources (HAGR) is a collection of online resources for studying the biology of human ageing. HAGR features two main databases: GenAge and AnAge. GenAge is a curated database of genes related to human ageing. Entries were primarily selected based on genetic perturbations in animal models and human diseases as well as an extensive literature review. Each entry includes a variety of automated and manually curated information, including, where available, protein-protein interactions, the relevant literature, and a description of the gene and how it relates to human ageing. The goal of GenAge is to provide the most complete and comprehensive database of genes related to human ageing on the Internet as well as render an overview of the genetics of human ageing. AnAge is an integrative database describing the ageing process in several organisms and featuring, if available, maximum life span, taxonomy, developmental schedules and metabolic rate, making AnAge a unique resource for the comparative biology of ageing. Associated with the databases are data-mining tools and software designed to investigate the role of genes and proteins in the human ageing process as well as analyse ageing across different taxa. HAGR is freely available to the academic community at http://genomics.senescence.info.

PubMed Disclaimer

Figures

Figure 1
Figure 1
GenAge entry for CKN1, Cockayne syndrome type 1. This entry includes basic information regarding the CKN1 gene and protein, a description of CKN1's relevance to ageing research, CKN1's protein–protein interactions, homologues in model organisms, a selection of references regarding CKN1 and its possible involvement in human ageing, and an extensive list of hyperlinks to external resources.
Figure 2
Figure 2
AnAge entry for the tiger salamander, Ambystoma tigrinum. This entry includes the taxonomy of the tiger salamander, its maximum life span, life history traits and a description of its ageing phenotype. Information on metabolism is also displayed as well as a selection of references and hyperlinks to external resources.
Figure 3
Figure 3
(A) Global protein–protein interaction map of GenAge. A total of 502 protein–protein interactions are displayed. The WRN protein is highlighted in blue and connecting nodes, with one degree of freedom, are highlighted in red. Layout computed and displayed using InterViewer 3.7 (Inha University, WI Lab, South Korea). (B) Magnification of the WRN network taken from the global protein–protein interaction map using InterViewer 3.7 (Inha University, WI Lab, South Korea). (C) Protein–protein interactions of WRN with one degree of freedom as generated by IGD. Entries identified through their relevance to human (red) or mammalian ageing (blue) are displayed in different colours. Genes only indirectly associated with ageing are displayed using a non-bold font.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Hayflick L. (2000) The future of ageing. Nature, 408, 267–269. - PubMed
    1. Butler R.N., Austad,S.N., Barzilai,N., Braun,A., Helfand,S., Larsen,P.L., McCormick,A.M., Perls,T.T., Shuldiner,A.R., Sprott,R.L. et al. (2003) Longevity genes: from primitive organisms to humans. J. Gerontol. A Biol. Sci. Med. Sci., 58, 581–584. - PubMed
    1. de Magalhaes J.P. and Toussaint,O. (2004) How bioinformatics can help reverse engineer human aging. Ageing Res. Rev., 3, 125–141. - PubMed
    1. Martin G.M. and Oshima,J. (2000) Lessons from human progeroid syndromes. Nature, 408, 263–266. - PubMed
    1. Pound P., Ebrahim,S., Sandercock,P., Bracken,M.B. and Roberts,I. (2004) Where is the evidence that animal research benefits humans? Br. Med. J., 328, 514–517. - PMC - PubMed

Publication types

  NODES
Association 1
chat 1
COMMUNITY 1
INTERN 1
twitter 2