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Review
. 2004 Nov;35(8-9):839-44.
doi: 10.1007/s10735-004-1833-2.

Classical cadherin adhesion molecules: coordinating cell adhesion, signaling and the cytoskeleton

Marita Goodwin  1 , Alpha S Yap
Affiliations
Review

Classical cadherin adhesion molecules: coordinating cell adhesion, signaling and the cytoskeleton

Marita Goodwin et al. J Mol Histol. 2004 Nov.

Abstract

Classical cadherin adhesion molecules are fundamental determinants of tissue organization in both health and disease. Recent advances in understanding the molecular and cellular basis of cadherin function have revealed that these adhesion molecules serve as molecular couplers, linking cell surface adhesion and recognition to both the actin cytoskeleton and cell signalling pathways. We will review some of these developments, to provide an overview of progress in this rapidly-developing area of cell and developmental biology.

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