Cardiovascular risk factors emerge after artificial selection for low aerobic capacity
- PMID: 15662013
- DOI: 10.1126/science.1108177
Cardiovascular risk factors emerge after artificial selection for low aerobic capacity
Abstract
In humans, the strong statistical association between fitness and survival suggests a link between impaired oxygen metabolism and disease. We hypothesized that artificial selection of rats based on low and high intrinsic exercise capacity would yield models that also contrast for disease risk. After 11 generations, rats with low aerobic capacity scored high on cardiovascular risk factors that constitute the metabolic syndrome. The decrease in aerobic capacity was associated with decreases in the amounts of transcription factors required for mitochondrial biogenesis and in the amounts of oxidative enzymes in skeletal muscle. Impairment of mitochondrial function may link reduced fitness to cardiovascular and metabolic disease.
Comment in
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Medicine. Low-power mitochondria may raise risk of cardiovascular problems.Science. 2005 Jan 21;307(5708):334-5. doi: 10.1126/science.307.5708.334a. Science. 2005. PMID: 15661980 No abstract available.
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