The signal recognition particle and its interactions during protein _targeting
- PMID: 15718142
- DOI: 10.1016/j.sbi.2005.01.013
The signal recognition particle and its interactions during protein _targeting
Abstract
The synthesis of secretory or integral membrane proteins can be directly coupled to their translocation across or insertion into membranes. In co-translational _targeting, the translation machine, the ribosome, is transferred to the respective membrane by the signal recognition particle (SRP) and its receptor (SR) as soon as a signal sequence emerges. Protein synthesis can continue at the membrane, with the nascent peptide chain directly inserting into the ribosome-bound protein-conducting channel, the Sec61 complex. During the past two years, several structures have been solved by crystallography and cryo-electron microscopy that represent distinct functional states of the SRP cycle. On this basis, the first structure-based models can be suggested that explain important aspects of protein _targeting, such as the SRP-ribosome and SRP-SR interactions.
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