Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2005 Mar;178(2-3):115-24.
doi: 10.1007/s00213-004-2015-3. Epub 2004 Oct 30.

Neuropeptide expression in rats exposed to chronic mild stresses

Valeriy Sergeyev  1 , Serguei Fetissov, Aleksander A Mathé, Patricia A Jimenez, Tamas Bartfai, Patrick Mortas, Laurent Gaudet, Jean-Luc Moreau, Tomas Hökfelt
Affiliations

Neuropeptide expression in rats exposed to chronic mild stresses

Valeriy Sergeyev et al. Psychopharmacology (Berl). 2005 Mar.

Abstract

To investigate a possible link between some neuropeptides and depression, we analyzed their mRNA levels in brains of rats exposed to chronic mild stresses (CMS; a stress-induced anhedonia model), a commonly used model of depression. Rats exposed for 3 weeks to repeated, unpredictable, mild stressors exhibited an increased self-stimulation threshold, reflecting the development of an anhedonic state, which is regarded as an animal model of major depression. In situ hybridization was employed to monitor mRNA levels of neuropeptide Y (NPY), substance P and galanin in several brain regions. In the CMS rats, NPY mRNA expression levels were significantly decreased in the hippocampal dentate gyrus but increased in the arcuate nucleus. The substance P mRNA levels were increased in the anterodorsal part of the medial amygdaloid nucleus, in the ventromedial and dorsomedial hypothalamic nuclei and the lateral hypothalamic area, whereas galanin mRNA levels were decreased in the latter two regions. These findings suggest a possible involvement of these three peptides in mechanisms underlying depressive disorders and show that similar peptide changes previously demonstrated in genetic rat models also occur in the present stress-induced anhedonia model.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Neurosci. 1986 Dec;6(12):3640-54 - PubMed
    1. Neuropsychopharmacology. 2002 May;26(5):615-24 - PubMed
    1. Neuropharmacology. 1987 Jun;26(6):581-90 - PubMed
    1. Neuropsychopharmacology. 1999 Oct;21(4):507-12 - PubMed
    1. Pharmacol Biochem Behav. 1996 May;54(1):229-34 - PubMed

Publication types

MeSH terms

LinkOut - more resources

  NODES
twitter 2