Signalling pathways regulating the invasive differentiation of human trophoblasts: a review
- PMID: 15837062
- DOI: 10.1016/j.placenta.2004.11.013
Signalling pathways regulating the invasive differentiation of human trophoblasts: a review
Abstract
The invasive differentiation pathway of trophoblasts is an indispensable physiological process of early human placental development. Formation of anchoring villi, proliferation of cell columns and invasion of extravillous cytotrophoblasts into maternal decidual stroma and vessels induce vascular changes ensuring an adequate blood supply to the growing fetus. Extravillous trophoblast differentiation is regulated by numerous growth factors as well as by extracellular matrix proteins and adhesion molecules expressed at the fetal-maternal interface. These regulatory molecules control cell invasion by modulating activities of matrix-degrading protease systems and ECM adhesion. The differentiation process involves numerous signalling cascades/proteins such as the GTPases RhoA, the protein kinases ROCK, ERK1, ERK2, FAK, PI3K, Akt/protein kinase B and mTOR as well as TGF-beta-dependent SMAD factors. While an increasing number of signalling pathways regulating trophoblast differentiation are being unravelled, downstream effectors such as executing transcription factors remain largely elusive. Here, we summarise our current knowledge on signal transduction cascades regulating invasive trophoblast differentiation. We will focus on cell model systems which are used to study the particular differentiation process and discuss signalling pathways which regulate trophoblast proliferation and motility.
Similar articles
-
Trophoblast giant-cell differentiation involves changes in cytoskeleton and cell motility.Dev Biol. 2001 Feb 1;230(1):43-60. doi: 10.1006/dbio.2000.0102. Dev Biol. 2001. PMID: 11161561
-
NME1 at the human maternal-fetal interface downregulates titin expression and invasiveness of trophoblast cells via MAPK pathway in early pregnancy.Reproduction. 2010 Apr;139(4):799-808. doi: 10.1530/REP-09-0490. Epub 2010 Feb 9. Reproduction. 2010. PMID: 20145075
-
Caveolin-1 and lipid rafts in confluent BeWo trophoblasts: evidence for Rock-1 association with caveolin-1.Placenta. 2007 Feb-Mar;28(2-3):139-51. doi: 10.1016/j.placenta.2005.12.005. Epub 2006 Feb 16. Placenta. 2007. PMID: 16480767
-
Governing the invasive trophoblast: current aspects on intra- and extracellular regulation.Am J Reprod Immunol. 2010 Jun;63(6):492-505. doi: 10.1111/j.1600-0897.2010.00824.x. Epub 2010 Mar 17. Am J Reprod Immunol. 2010. PMID: 20236263 Review.
-
Critical growth factors and signalling pathways controlling human trophoblast invasion.Int J Dev Biol. 2010;54(2-3):269-80. doi: 10.1387/ijdb.082769mk. Int J Dev Biol. 2010. PMID: 19876833 Free PMC article. Review.
Cited by
-
Endogenous retroviruses in trophoblast differentiation and placental development.Am J Reprod Immunol. 2010 Oct;64(4):255-64. doi: 10.1111/j.1600-0897.2010.00860.x. Epub 2010 May 26. Am J Reprod Immunol. 2010. PMID: 20528833 Free PMC article. Review.
-
Human chorionic gonadotropin stimulates trophoblast invasion through extracellularly regulated kinase and AKT signaling.Endocrinology. 2008 Mar;149(3):979-87. doi: 10.1210/en.2007-1282. Epub 2007 Dec 6. Endocrinology. 2008. PMID: 18063683 Free PMC article.
-
A Comparative Review of Pregnancy and Cancer and Their Association with Endoplasmic Reticulum Aminopeptidase 1 and 2.Int J Mol Sci. 2023 Feb 9;24(4):3454. doi: 10.3390/ijms24043454. Int J Mol Sci. 2023. PMID: 36834865 Free PMC article. Review.
-
Proteomic analysis of knock-down HLA-G in invasion of human trophoblast cell line JEG-3.Int J Clin Exp Pathol. 2013 Oct 15;6(11):2451-9. eCollection 2013. Int J Clin Exp Pathol. 2013. PMID: 24228107 Free PMC article.
-
Transforming growth factor Beta regulates proliferation and invasion of rat placental cell lines.Biol Reprod. 2011 Mar;84(3):553-9. doi: 10.1095/biolreprod.110.086348. Epub 2010 Oct 6. Biol Reprod. 2011. PMID: 20926802 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous
