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Review
. 2005 Sep 8;227(1):1-7.
doi: 10.1016/j.canlet.2004.11.006. Epub 2004 Dec 13.

BRCA1 in breast and ovarian cancer predisposition

Blase Billack  1 , Alvaro N A Monteiro
Affiliations
Review

BRCA1 in breast and ovarian cancer predisposition

Blase Billack et al. Cancer Lett. .

Abstract

Women carrying one mutated BRCA1 allele are at increased risk of developing breast and ovarian cancer but tumor initiation requires the loss of the wild-type allele indicating that it is a tumor suppressor gene. In the 10 years since the cloning of BRCA1, a function for the gene product in the DNA damage response has been established. However, identifying the exact biochemical activities of BRCA1 has been a more difficult task. Our current understanding suggests that the molecular functions mediated by the terminal ends of BRCA1, which include an E3 ubiquitin ligase activity at the N-terminus and a protein-protein interaction surface at the C-terminus, are critical to the function of this protein in the response to DNA damage.

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