Lipoproteins, macrophage function, and atherosclerosis: beyond the foam cell?
- PMID: 16054067
- DOI: 10.1016/j.cmet.2005.03.005
Lipoproteins, macrophage function, and atherosclerosis: beyond the foam cell?
Abstract
Atherogenesis requires and is highly influenced by the interaction between lipoproteins and macrophages. Most of the focus to date has been on the ability of atherogenic lipoproteins (such as low-density lipoproteins, LDL) to promote and of anti-atherogenic lipoproteins (such as high-density lipoproteins, HDL) to prevent the development of the cholesteryl ester-enriched macrophage-derived foam cell. However, lipoprotein-macrophage interactions have the potential to modulate macrophage function in a variety of additional ways that may impact on atherosclerosis. These include modulating cellular cholesterol and oxysterol content, providing fatty acids as ligands for PPARs, and acting as ligands for macrophage scavenger and Toll-like receptors. We suggest that atherogenic lipoproteins promote and anti-atherogenic lipoproteins inhibit atherogenesis by modulating macrophage function in a variety of ways beyond cholesteryl ester accumulation and foam cell formation.
Similar articles
-
Three probe flow cytometry of a human foam-cell forming macrophage.Cytometry. 1992;13(4):381-8. doi: 10.1002/cyto.990130408. Cytometry. 1992. PMID: 1526197
-
Macrophage foam cell formation during early atherogenesis is determined by the balance between pro-oxidants and anti-oxidants in arterial cells and blood lipoproteins.Antioxid Redox Signal. 1999 Winter;1(4):585-94. doi: 10.1089/ars.1999.1.4-585. Antioxid Redox Signal. 1999. PMID: 11233155 Review.
-
Triglyceride-rich lipoproteins and atherosclerosis: pathophysiological considerations.J Intern Med Suppl. 1994;736:33-9. J Intern Med Suppl. 1994. PMID: 7986306 Review.
-
Impact of salusin-alpha and -beta on human macrophage foam cell formation and coronary atherosclerosis.Circulation. 2008 Feb 5;117(5):638-48. doi: 10.1161/CIRCULATIONAHA.107.712539. Epub 2008 Jan 22. Circulation. 2008. PMID: 18212280
-
Multifunctional roles of macrophages in the development and progression of atherosclerosis in humans and experimental animals.Med Electron Microsc. 2002 Dec;35(4):179-203. doi: 10.1007/s007950200023. Med Electron Microsc. 2002. PMID: 12658354 Review.
Cited by
-
18FDG PET-CT imaging detects arterial inflammation and early atherosclerosis in HIV-infected adults with cardiovascular disease risk factors.J Inflamm (Lond). 2012 Jun 22;9(1):26. doi: 10.1186/1476-9255-9-26. J Inflamm (Lond). 2012. PMID: 22726233 Free PMC article.
-
Research Progress and Molecular Mechanisms of Endothelial Cells Inflammation in Vascular-Related Diseases.J Inflamm Res. 2023 Aug 23;16:3593-3617. doi: 10.2147/JIR.S418166. eCollection 2023. J Inflamm Res. 2023. PMID: 37641702 Free PMC article. Review.
-
MicroRNAs in cardiometabolic disease.Curr Atheroscler Rep. 2011 Jun;13(3):202-7. doi: 10.1007/s11883-011-0179-y. Curr Atheroscler Rep. 2011. PMID: 21461683 Review.
-
Insights into the regulatory role of Plexin D1 signalling in cardiovascular development and diseases.J Cell Mol Med. 2021 May;25(9):4183-4194. doi: 10.1111/jcmm.16509. Epub 2021 Apr 9. J Cell Mol Med. 2021. PMID: 33837646 Free PMC article. Review.
-
Intracellular degradation of microspheres based on cross-linked dextran hydrogels or amphiphilic block copolymers: a comparative raman microscopy study.Int J Nanomedicine. 2007;2(2):241-52. Int J Nanomedicine. 2007. PMID: 17722552 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
