Comparative Study
doi: 10.1038/nn1521.
Epub 2005 Aug 7.
Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus
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- PMID: 16116451
- DOI: 10.1038/nn1521
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Comparative Study
Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus
Nat Neurosci.
2005 Sep.
Free article
Erratum in
- Nat Neurosci. 2007 Jan;10(1):134
Abstract
The functions of 2-arachidonoylglycerol (2-AG), the most abundant endocannabinoid found in the brain, remain largely unknown. Here we show that two previously unknown inhibitors of monoacylglycerol lipase, a presynaptic enzyme that hydrolyzes 2-AG, increase 2-AG levels and enhance retrograde signaling from pyramidal neurons to GABAergic terminals in the hippocampus. These results establish a role for 2-AG in synaptic plasticity and point to monoacylglycerol lipase as a possible drug _target.
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