Review
doi: 10.1038/nrc1692.
The role of autophagy in cancer development and response to therapy
Affiliations
- PMID: 16148885
- DOI: 10.1038/nrc1692
Item in Clipboard
Review
The role of autophagy in cancer development and response to therapy
Nat Rev Cancer.
2005 Sep.
Abstract
Autophagy is a process in which subcellular membranes undergo dynamic morphological changes that lead to the degradation of cellular proteins and cytoplasmic organelles. This process is an important cellular response to stress or starvation. Many studies have shed light on the importance of autophagy in cancer, but it is still unclear whether autophagy suppresses tumorigenesis or provides cancer cells with a rescue mechanism under unfavourable conditions. What is the present state of our knowledge about the role of autophagy in cancer development, and in response to therapy? And how can the autophagic process be manipulated to improve anticancer therapeutics?
Similar articles
-
Autophagy signaling in cancer and its potential as novel _target to improve anticancer therapy.Drug Resist Updat. 2007 Aug-Oct;10(4-5):135-43. doi: 10.1016/j.drup.2007.05.001. Epub 2007 Jul 12. Drug Resist Updat. 2007. PMID: 17627865 Review.
-
Autophagy: cancer therapy's friend or foe?Future Med Chem. 2010 Feb;2(2):285-97. doi: 10.4155/fmc.09.155. Future Med Chem. 2010. PMID: 21426194 Review.
-
Life, death and burial: multifaceted impact of autophagy.Biochem Soc Trans. 2008 Oct;36(Pt 5):786-90. doi: 10.1042/BST0360786. Biochem Soc Trans. 2008. PMID: 18793137 Review.
-
The roles of therapy-induced autophagy and necrosis in cancer treatment.Clin Cancer Res. 2007 Dec 15;13(24):7271-9. doi: 10.1158/1078-0432.CCR-07-1595. Clin Cancer Res. 2007. PMID: 18094407 Review.
-
Autophagy in cancer: good, bad, or both?Cancer Res. 2006 Oct 1;66(19):9349-51. doi: 10.1158/0008-5472.CAN-06-1597. Cancer Res. 2006. PMID: 17018585 Review.
Cited by
-
Autophagy inhibition for chemosensitization and radiosensitization in cancer: do the preclinical data support this therapeutic strategy?J Pharmacol Exp Ther. 2013 Mar;344(3):544-52. doi: 10.1124/jpet.112.199802. Epub 2013 Jan 4. J Pharmacol Exp Ther. 2013. PMID: 23291713 Free PMC article.
-
Autophagy markers as mediators of lung injury-implication for therapeutic intervention.Life Sci. 2020 Nov 1;260:118308. doi: 10.1016/j.lfs.2020.118308. Epub 2020 Aug 21. Life Sci. 2020. PMID: 32828942 Free PMC article. Review.
-
Autophagy inhibition enhances apoptosis induced by dioscin in huh7 cells.Evid Based Complement Alternat Med. 2012;2012:134512. doi: 10.1155/2012/134512. Epub 2012 Nov 5. Evid Based Complement Alternat Med. 2012. PMID: 23193420 Free PMC article.
-
_targeting MKK3 as a novel anticancer strategy: molecular mechanisms and therapeutical implications.Cell Death Dis. 2015 Jan 29;6(1):e1621. doi: 10.1038/cddis.2014.591. Cell Death Dis. 2015. PMID: 25633290 Free PMC article.
-
_targeting the mTOR-DEPTOR pathway by CRL E3 ubiquitin ligases: therapeutic application.Neoplasia. 2012 May;14(5):360-7. doi: 10.1593/neo.12532. Neoplasia. 2012. PMID: 22745582 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
