Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2006 Mar;243(3):321-8.
doi: 10.1097/01.sla.0000201480.65519.b8.

A prospective randomized trial comparing percutaneous local ablative therapy and partial hepatectomy for small hepatocellular carcinoma

Min-Shan Chen  1 , Jin-Qing Li, Yun Zheng, Rong-Ping Guo, Hui-Hong Liang, Ya-Qi Zhang, Xiao-Jun Lin, Wan Y Lau
Affiliations
Randomized Controlled Trial

A prospective randomized trial comparing percutaneous local ablative therapy and partial hepatectomy for small hepatocellular carcinoma

Min-Shan Chen et al. Ann Surg. 2006 Mar.

Abstract

Objective: To compare the results of percutaneous local ablative therapy (PLAT) with surgical resection in the treatment of solitary and small hepatocellular carcinoma (HCC).

Summary background data: PLAT is effective in small HCC. Whether it is as effective as surgical resection in the long-term survivals remains unknown.

Methods: We conducted a prospective randomized trial on 180 patients with a solitary HCC <or=5 cm to receive either PLAT or surgical resection. The patients were regularly followed up after treatment with physical examination, blood, and radiologic tests.

Results: Of the 90 patients who were randomized to PLAT, only 71 received PLAT because 19 withdrew their consent. Of the 90 patients who were randomized to surgical resection, a single Couinaud liver segment resection was carried out in 69 patients, 2 segments in 16 patients, and 3 or more segments in 3 patients. Ethanol injection was given during open surgery in 2 patients. Only 1 patient died after surgical resection within the same hospital admission. Posttreatment complications were more often and severe after surgery than PLAT. The 1-, 2-, 3-, and 4-year overall survival rates after PLAT and surgery were 95.8%, 82.1%, 71.4%, 67.9% and 93.3%, 82.3%, 73.4%, 64.0%, respectively. The corresponding disease-free survival rates were 85.9%, 69.3%, 64.1%, 46.4% and 86.6%, 76.8%, 69%, 51.6%, respectively. Statistically, there was no difference between these 2 treatments.

Conclusion: PLAT was as effective as surgical resection in the treatment of solitary and small HCC. PLAT had the advantage over surgical resection in being less invasive.

PubMed Disclaimer

Figures

None
FIGURE 1. Patient numbers for the intention-to-treat analysis.
None
FIGURE 2. Overall and disease-free survivals for patients randomized to percutaneous local ablative therapy (PLAT, n = 90, including 19 patients who withdrew their consent after randomization and received surgical resection) or surgical resection (SR).
None
FIGURE 3. Overall and disease-free survivals for patients randomized to percutaneous local ablative therapy (PLAT, n = 90, including 19 patients who withdrew their consent after randomization and received surgical resection) or surgical resection (SR) for tumors less than 3 cm (A), and between 3.1 cm and 5 cm (B).
None
FIGURE 4. Overall and disease-free survivals for patients treated with percutaneous local ablative therapy (PLAT, n = 71) or surgical resection (SR, n = 90).
None
FIGURE 5. Overall and disease-free survivals with percutaneous local ablative therapy (PLAT, n = 71) and surgical resection (SR, n = 90) for tumor less than 3 cm (A), and between 3.1 cm and 5 cm (B).
See this image and copyright information in PMC

Comment in

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Bosch X, Ribes J, Borras J. Epidemiology of primary liver cancer. Semin Liver Dis. 1999;19:271–285. - PubMed
    1. Taylor-Robinson SD, Foster GR, Arora S, et al. Increase in primary liver cancer in the UK 1979–94. Lancet. 1997;350:1142–1143. - PubMed
    1. El-Serag HB, Mason AC. Rising incidence of hepatocellular carcinoma in the United States. N Engl J Med. 1999;340:745–750. - PubMed
    1. Liver Cancer Study Group of Japan. Primary liver cancers in Japan. Cancer. 1980;45:2663–2669. - PubMed
    1. Lai EC, Fan ST, Lo CM, et al. Hepatic resection for hepatocellular carcinoma: an audit of 343 patients. Ann Surg. 1995;221:291–298. - PMC - PubMed

Publication types

  NODES
eth 6
see 3
Story 1
twitter 2