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. 2006 Feb;7(1):63-7.
doi: 10.1007/s10522-005-6038-x.

Organ- and tissue-specific alterations in the anti-apoptotic protein Bcl-2 in CD1 female mice of different ages

Hugo López-Araiza  1 , José L Ventura, Norma E López-Diazguerrero, Humberto González-Marquez, María C Gutiérrez-Ruíz, Alejandro Zentella, Mina Königsberg
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Organ- and tissue-specific alterations in the anti-apoptotic protein Bcl-2 in CD1 female mice of different ages

Hugo López-Araiza et al. Biogerontology. 2006 Feb.

Abstract

The anti-apoptotic protein Bcl-2, which also has cytoprotective and antioxidant functions might be one of the crucial factors that altogether, establish how a cell may deal with stress and damage, contributing to longevity. Among the controversial issues to understand Bcl-2 functions in vivo, is to establish its content and variation in tissues during an organismal lifespan. In this work we analyzed the changes of Bcl-2 levels in lung, liver, heart, kidney, spleen and brain homogenates obtained from CD1 mice throughout their lifespan (newborn to 24 months). A tendency of increment was observed in all the organs analyzed, except brain where Bcl-2 was not detected. Bcl-2 over-expression during aging could be interpreted as a protective mechanism preventing cell death, despite the overall accumulated cell damage.

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