Sesamin is one of the major precursors of mammalian lignans in sesame seed (Sesamum indicum) as observed in vitro and in rats
- PMID: 16549449
- DOI: 10.1093/jn/136.4.906
Sesamin is one of the major precursors of mammalian lignans in sesame seed (Sesamum indicum) as observed in vitro and in rats
Abstract
Plant lignans occur in many foods, with flaxseed presently recognized as the richest source. Some plant lignans can be converted by intestinal microbiota to the mammalian lignans, enterodiol and enterolactone, which may have protective effects against hormone-related diseases such as breast cancer. This study determined whether plant lignans in sesame seed, particularly sesamin, could be metabolized to the mammalian lignans. The total plant lignan concentration in sesame seed (2180 micromol/100 g) was higher than that in flaxseed (820 micromol/100 g). In vitro fermentation with human fecal inoculum showed conversion of sesamin to the mammalian lignans, although at a lower rate (1.1%) compared with that of secoisolariciresinol diglucoside (57.2%). However, when fed to female Sprague-Dawley rats for 10 d, sesamin (15 mg/kg body weight) and a 10% sesame seed diet resulted in greater (P < 0.05) urinary mammalian lignan excretion (3.2 and 11.2 micromol/d, respectively), than the control (< 0.05 micromol/d). We conclude that sesame seed is a rich source of mammalian lignan precursors and sesamin is one of them. From intermediate metabolites of sesamin identified in rat urine by GC-MS, a tentative metabolic pathway of sesamin to mammalian lignans is suggested.
Similar articles
-
Whole sesame seed is as rich a source of mammalian lignan precursors as whole flaxseed.Nutr Cancer. 2005;52(2):156-65. doi: 10.1207/s15327914nc5202_6. Nutr Cancer. 2005. PMID: 16201847 Clinical Trial.
-
Biotransformation of sesaminol triglucoside to mammalian lignans by intestinal microbiota.J Agric Food Chem. 2009 Jul 22;57(14):6101-6. doi: 10.1021/jf901215j. J Agric Food Chem. 2009. PMID: 19537732
-
Comparative effects of sesame seed lignan and flaxseed lignan in reducing the growth of human breast tumors (MCF-7) at high levels of circulating estrogen in athymic mice.Nutr Cancer. 2012;64(1):65-71. doi: 10.1080/01635581.2012.630165. Epub 2011 Dec 2. Nutr Cancer. 2012. PMID: 22136581
-
Lignans of Sesame (Sesamum indicum L.): A Comprehensive Review.Molecules. 2021 Feb 7;26(4):883. doi: 10.3390/molecules26040883. Molecules. 2021. PMID: 33562414 Free PMC article. Review.
-
A comprehensive review on the anti-cancer properties and mechanisms of action of sesamin, a lignan in sesame seeds (Sesamum indicum).Eur J Pharmacol. 2017 Nov 15;815:512-521. doi: 10.1016/j.ejphar.2017.10.020. Epub 2017 Oct 12. Eur J Pharmacol. 2017. PMID: 29032105 Review.
Cited by
-
Beneficial Effects of Polyphenol-Rich Food Oils in Cardiovascular Health and Disease.Rev Cardiovasc Med. 2023 Jul 3;24(7):190. doi: 10.31083/j.rcm2407190. eCollection 2023 Jul. Rev Cardiovasc Med. 2023. PMID: 39077008 Free PMC article. Review.
-
New Anti-Glycative Lignans from the Defatted Seeds of Sesamum indicum.Molecules. 2023 Feb 28;28(5):2255. doi: 10.3390/molecules28052255. Molecules. 2023. PMID: 36903500 Free PMC article.
-
Oxidative rearrangement of (+)-sesamin by CYP92B14 co-generates twin dietary lignans in sesame.Nat Commun. 2017 Dec 18;8(1):2155. doi: 10.1038/s41467-017-02053-7. Nat Commun. 2017. PMID: 29255253 Free PMC article.
-
Gastrointestinal microflora, food components and colon cancer prevention.J Nutr Biochem. 2009 Oct;20(10):743-52. doi: 10.1016/j.jnutbio.2009.06.001. Epub 2009 Aug 27. J Nutr Biochem. 2009. PMID: 19716282 Free PMC article. Review.
-
Value addition in sesame: A perspective on bioactive components for enhancing utility and profitability.Pharmacogn Rev. 2014 Jul;8(16):147-55. doi: 10.4103/0973-7847.134249. Pharmacogn Rev. 2014. PMID: 25125886 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous
