Review
doi: 10.1038/nrc1840.
Oncomirs - microRNAs with a role in cancer
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- PMID: 16557279
- DOI: 10.1038/nrc1840
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Review
Oncomirs - microRNAs with a role in cancer
Nat Rev Cancer.
2006 Apr.
Abstract
MicroRNAs (miRNAs) are an abundant class of small non-protein-coding RNAs that function as negative gene regulators. They regulate diverse biological processes, and bioinformatic data indicates that each miRNA can control hundreds of gene _targets, underscoring the potential influence of miRNAs on almost every genetic pathway. Recent evidence has shown that miRNA mutations or mis-expression correlate with various human cancers and indicates that miRNAs can function as tumour suppressors and oncogenes. miRNAs have been shown to repress the expression of important cancer-related genes and might prove useful in the diagnosis and treatment of cancer.
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