Th17: an effector CD4 T cell lineage with regulatory T cell ties

doi:10.1016/j.immuni.2006.06.002

Review

. 2006 Jun;24(6):677-688.

doi: 10.1016/j.immuni.2006.06.002.

Th17: an effector CD4 T cell lineage with regulatory T cell ties

Casey T Weaver¹, Laurie E Harrington², Paul R Mangan³, Maya Gavrieli⁴, Kenneth M Murphy⁴

Affiliations

¹ Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294; Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294. Electronic address: cweaver@uab.edu.
² Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294.
³ Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294.
⁴ Department of Pathology and Center for Immunology, Washington University School of Medicine, St. Louis, Missouri 63110; Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, Missouri 63110.

PMID: 16782025
DOI: 10.1016/j.immuni.2006.06.002

Free article

Review

Th17: an effector CD4 T cell lineage with regulatory T cell ties

Casey T Weaver et al. Immunity. 2006 Jun.

Free article

. 2006 Jun;24(6):677-688.

doi: 10.1016/j.immuni.2006.06.002.

Authors

Casey T Weaver¹, Laurie E Harrington², Paul R Mangan³, Maya Gavrieli⁴, Kenneth M Murphy⁴

Affiliations

¹ Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294; Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294. Electronic address: cweaver@uab.edu.
² Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294.
³ Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294.
⁴ Department of Pathology and Center for Immunology, Washington University School of Medicine, St. Louis, Missouri 63110; Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, Missouri 63110.

PMID: 16782025
DOI: 10.1016/j.immuni.2006.06.002

Abstract

The naive CD4 T cell is a multipotential precursor with defined antigen recognition specificity but substantial plasticity for development down distinct effector or regulatory lineages, contingent upon signals from cells of the innate immune system. The range of identified effector CD4 T cell lineages has recently expanded with description of an IL-17-producing subset, called Th17, which develops via cytokine signals distinct from, and antagonized by, products of the Th1 and Th2 lineages. Remarkably, Th17 development depends on the pleiotropic cytokine TGF-beta, which is also linked to regulatory T cell development and function, providing a unique mechanism for matching CD4 T cell effector and regulatory lineage specification. Here, we review Th17 lineage development, emphasizing similarities and differences with established effector and regulatory T cell developmental programs that have important implications for immune regulation, immune pathogenesis, and host defense.

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Th17: an effector CD4 T cell lineage with regulatory T cell ties

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Th17: an effector CD4 T cell lineage with regulatory T cell ties

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