Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2006 Sep 15;23(6):899-911.
doi: 10.1016/j.molcel.2006.07.028.

JNK2 is a positive regulator of the cJun transcription factor

Anja Jaeschke  1 , Maria Karasarides, Juan-Jose Ventura, Anka Ehrhardt, Chao Zhang, Richard A Flavell, Kevan M Shokat, Roger J Davis
Affiliations
Free article
Comparative Study

JNK2 is a positive regulator of the cJun transcription factor

Anja Jaeschke et al. Mol Cell. .
Free article

Abstract

The cJun NH(2)-terminal kinase (JNK) signal transduction pathway is established to be an important mechanism of regulation of the cJun transcription factor. Studies of Jnk1(-/-) and Jnk2(-/-) mice suggest that the JNK1 and JNK2 isoforms have opposite effects on cJun expression and proliferation. Here, we demonstrate, using a chemical genetic approach, that both JNK1 and JNK2 are positive regulators of these processes. We show that competition between JNK1 and JNK2 contributes to the opposite phenotypes caused by JNK1 and JNK2 deficiency. Our analysis illustrates the power of a chemical genetics approach for the analysis of signal transduction pathways and also highlights the limitations of single gene knockout strategies for the analysis of signaling pathways that are formed by a network of interacting proteins.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Publication types

MeSH terms

Substances

  NODES
eth 2
see 2
Story 1
twitter 2