Interferons, immunity and cancer immunoediting
- PMID: 17063185
- DOI: 10.1038/nri1961
Interferons, immunity and cancer immunoediting
Abstract
A clear picture of the dynamic relationship between the host immune system and cancer is emerging as the cells and molecules that participate in naturally occurring antitumour immune responses are being identified. The interferons (IFNs) - that is, the type I IFNs (IFNalpha and IFNbeta) and type II IFN (IFNgamma) - have emerged as central coordinators of tumour-immune-system interactions. Indeed, the decade-old finding that IFNgamma has a pivotal role in promoting antitumour responses became the focus for a renewed interest in the largely abandoned concept of cancer immunosurveillance. More recently, type I IFNs have been found to have distinct functions in this process. In this Review, we discuss the roles of the IFNs, not only in cancer immunosurveillance but also in the broader process of cancer immunoediting.
Similar articles
-
Cancer immunosurveillance and immunoediting: the roles of immunity in suppressing tumor development and shaping tumor immunogenicity.Adv Immunol. 2006;90:1-50. doi: 10.1016/S0065-2776(06)90001-7. Adv Immunol. 2006. PMID: 16730260 Review.
-
Cytokines in cancer immunity and immunotherapy.Immunol Rev. 2004 Dec;202:275-93. doi: 10.1111/j.0105-2896.2004.00199.x. Immunol Rev. 2004. PMID: 15546400 Review.
-
Interferons in cancer immunoediting: sculpting metastasis and immunotherapy response.J Clin Invest. 2021 Jan 4;131(1):e143296. doi: 10.1172/JCI143296. J Clin Invest. 2021. PMID: 33393507 Free PMC article. Review.
-
Cancer despite immunosurveillance: immunoselection and immunosubversion.Nat Rev Immunol. 2006 Oct;6(10):715-27. doi: 10.1038/nri1936. Epub 2006 Sep 15. Nat Rev Immunol. 2006. PMID: 16977338 Review.
-
IFN-alpha in the generation of dendritic cells for cancer immunotherapy.Handb Exp Pharmacol. 2009;(188):295-317. doi: 10.1007/978-3-540-71029-5_14. Handb Exp Pharmacol. 2009. PMID: 19031032 Review.
Cited by
-
IFNAR1 is a predictor for overall survival in colorectal cancer and its mRNA expression correlated with IRF7 but not TLR9.Medicine (Baltimore). 2014 Dec;93(29):e349. doi: 10.1097/MD.0000000000000349. Medicine (Baltimore). 2014. PMID: 25546690 Free PMC article.
-
Unraveling the Intricacies of CD73/Adenosine Signaling: The Pulmonary Immune and Stromal Microenvironment in Lung Cancer.Cancers (Basel). 2023 Dec 4;15(23):5706. doi: 10.3390/cancers15235706. Cancers (Basel). 2023. PMID: 38067409 Free PMC article. Review.
-
Increased Soluble CD155 in the Serum of Cancer Patients.PLoS One. 2016 Apr 6;11(4):e0152982. doi: 10.1371/journal.pone.0152982. eCollection 2016. PLoS One. 2016. PMID: 27049654 Free PMC article.
-
_targeting interferons in systemic lupus erythematosus: current and future prospects.Drugs. 2015 May;75(8):835-46. doi: 10.1007/s40265-015-0394-x. Drugs. 2015. PMID: 25940912 Review.
-
Adoptively transferred natural killer cells maintain long-term antitumor activity by epigenetic imprinting and CD4+ T cell help.Oncoimmunology. 2016 Aug 5;5(9):e1219009. doi: 10.1080/2162402X.2016.1219009. eCollection 2016. Oncoimmunology. 2016. PMID: 27757318 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
