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Review
. 2006 Dec 14;444(7121):881-7.
doi: 10.1038/nature05488.

Abdominal obesity and metabolic syndrome

Jean-Pierre Després  1 , Isabelle Lemieux
Affiliations
Review

Abdominal obesity and metabolic syndrome

Jean-Pierre Després et al. Nature. .

Abstract

Metabolic syndrome is associated with abdominal obesity, blood lipid disorders, inflammation, insulin resistance or full-blown diabetes, and increased risk of developing cardiovascular disease. Proposed criteria for identifying patients with metabolic syndrome have contributed greatly to preventive medicine, but the value of metabolic syndrome as a scientific concept remains controversial. The presence of metabolic syndrome alone cannot predict global cardiovascular disease risk. But abdominal obesity - the most prevalent manifestation of metabolic syndrome - is a marker of 'dysfunctional adipose tissue', and is of central importance in clinical diagnosis. Better risk assessment algorithms are needed to quantify diabetes and cardiovascular disease risk on a global scale.

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