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. 2007 Feb 21;413(3):196-201.
doi: 10.1016/j.neulet.2006.11.046. Epub 2006 Dec 15.

Effects of carbonic anhydrase VIII deficiency on cerebellar gene expression profiles in the wdl mouse

Jian Yan  1 , Yan Jiao, Feng Jiao, John Stuart, Leah Rae Donahue, Wesley G Beamer, Xinmin Li, Bruce A Roe, Mark S LeDoux, Weikuan Gu
Affiliations

Effects of carbonic anhydrase VIII deficiency on cerebellar gene expression profiles in the wdl mouse

Jian Yan et al. Neurosci Lett. .

Abstract

Recently, the waddles (wdl) mouse was identified as a carbonic anhydrase VIII (Car8) mutant. The mutation is associated with marked deficiency of Car8, an inositol triphosphate receptor 1-binding protein expressed at high levels in cerebellar Purkinje cells. To help unravel the molecular aberrations contributing to motor dysfunction in wdl mice, cerebellar gene expression profiles were examined in the mutants and their wild-type littermates. Genes involved in signaling, cell division, zinc ion-binding, synapse integrity and plasticity were downregulated in wdl mice. Several of the upregulated genes encode proteins that function in the Golgi apparatus which suggests that Car8 deficiency has important effects on synaptic vesicle formation and transport.

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References

    1. Akhmanova A, Hoogenraad CC, Drabek K, Stepanova T, Dortland B, Verkerk T, Vermeulen W, Burgering BM, De Zeeuw CI, Grosveld F, Galjart N. Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts. Cell. 2001;104:923–35. - PubMed
    1. Arber S, Ladle DR, Lin JH, Frank E, Jessell TM. ETS gene Er81 controls the formation of functional connections between group Ia sensory afferents and motor neurons. Cell. 2000;101:485–98. - PubMed
    1. Aruga J, Minowa O, Yaginuma H, Kuno J, Nagai T, Noda T, Mikoshiba K. Mouse Zic1 is involved in cerebellar development. J Neurosci. 1998;18:284–93. - PMC - PubMed
    1. Bastianelli E. Distribution of calcium-binding proteins in the cerebellum. Cerebellum. 2003;2:242–62. - PubMed
    1. Berridge MJ. Neuronal calcium signaling. Neuron. 1998;21:13–26. - PubMed

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