Review
doi: 10.1038/nrc2047.
Myelodysplastic syndromes: the complexity of stem-cell diseases
Affiliations
- PMID: 17251918
- DOI: 10.1038/nrc2047
Item in Clipboard
Review
Myelodysplastic syndromes: the complexity of stem-cell diseases
Nat Rev Cancer.
2007 Feb.
Abstract
The prevalence of patients with myelodysplastic syndromes (MDS) is increasing owing to an ageing population and increased awareness of these diseases. MDS represent many different conditions, not just a single disease, that are grouped together by several clinical characteristics. A striking feature of MDS is genetic instability, and a large proportion of cases result in acute myeloid leukaemia (AML). We Review three emerging principles of MDS biology: stem-cell dysfunction and the overlap with AML, genetic instability and the deregulation of apoptosis, in the context of inherited bone marrow-failure syndromes, and treatment-related MDS and AML.
Similar articles
-
Exisulind induces apoptosis in advanced myelodysplastic syndrome (MDS) and acute myeloid leukaemia/MDS.Br J Haematol. 2006 Nov;135(3):355-7. doi: 10.1111/j.1365-2141.2006.06298.x. Epub 2006 Sep 15. Br J Haematol. 2006. PMID: 16978222
-
Histopathology in the diagnosis and classification of acute myeloid leukemia, myelodysplastic syndromes, and myelodysplastic/myeloproliferative diseases.Pathobiology. 2007;74(2):97-114. doi: 10.1159/000101709. Pathobiology. 2007. PMID: 17587881 Review.
-
Molecular pathways in myelodysplastic syndromes and acute myeloid leukemia: relationships and distinctions-a review.Br J Haematol. 2008 Sep;142(5):695-708. doi: 10.1111/j.1365-2141.2008.07245.x. Epub 2008 Jun 5. Br J Haematol. 2008. PMID: 18540941 Review.
-
Therapy-related myelodysplastic syndrome: morphologic subclassification may not be clinically relevant.Am J Clin Pathol. 2007 Feb;127(2):197-205. doi: 10.1309/NQ3PMV4U8YV39JWJ. Am J Clin Pathol. 2007. PMID: 17210514
-
Bone marrow mononuclear cells of MDS patients are characterized by in vitro proliferation and increased apoptosis independently of stromal interactions.Leuk Res. 2007 Dec;31(12):1659-67. doi: 10.1016/j.leukres.2007.06.013. Epub 2007 Jul 30. Leuk Res. 2007. PMID: 17659774
Cited by
-
Spliceosome mutations exhibit specific associations with epigenetic modifiers and proto-oncogenes mutated in myelodysplastic syndrome.Haematologica. 2013 Jul;98(7):1058-66. doi: 10.3324/haematol.2012.075325. Epub 2013 Jan 8. Haematologica. 2013. PMID: 23300180 Free PMC article.
-
Perturbed hematopoietic stem and progenitor cell hierarchy in myelodysplastic syndromes patients with monosomy 7 as the sole cytogenetic abnormality.Onco_target. 2016 Nov 8;7(45):72685-72698. doi: 10.18632/onco_target.12234. Onco_target. 2016. PMID: 27683035 Free PMC article.
-
Innate immune pathways and inflammation in hematopoietic aging, clonal hematopoiesis, and MDS.J Exp Med. 2021 Jul 5;218(7):e20201544. doi: 10.1084/jem.20201544. Epub 2021 Jun 15. J Exp Med. 2021. PMID: 34129017 Free PMC article. Review.
-
Random walk with restart on multilayer networks: from node prioritisation to supervised link prediction and beyond.BMC Bioinformatics. 2024 Feb 14;25(1):70. doi: 10.1186/s12859-024-05683-z. BMC Bioinformatics. 2024. PMID: 38355439 Free PMC article.
-
Disease-associated mutation in SRSF2 misregulates splicing by altering RNA-binding affinities.Proc Natl Acad Sci U S A. 2015 Aug 25;112(34):E4726-34. doi: 10.1073/pnas.1514105112. Epub 2015 Aug 10. Proc Natl Acad Sci U S A. 2015. PMID: 26261309 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials
Miscellaneous
