Review
doi: 10.1007/s00726-007-0500-9.
Epub 2007 Mar 3.
S-adenosylmethionine and its products
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- PMID: 17334902
- DOI: 10.1007/s00726-007-0500-9
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Review
S-adenosylmethionine and its products
Amino Acids.
2008 Feb.
Abstract
S-adenosylmethionine is involved in many processes, mainly methylation, polyamine synthesis and radical-based catalysis. It is synthesised through the catalysis of differently regulated enzyme forms. When it is used, the compounds formed are reutilized in different ways: in case of methylation, its end product is homocysteine, which can be remethylated to methionine, give rise to cysteine in the so-called transsulphuration pathway, or be released; in the case of polyamine synthesis, the methylthioadenosine formed is cleaved and gives rise to compounds which can be reutilized; during radical-based catalysis, 5-deoxyadenosine is formed and this, too, is cleaved and reutilized.
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