Cytomegalovirus evasion of innate immunity by subversion of the NKR-P1B:Clr-b missing-self axis
- PMID: 17462921
- DOI: 10.1016/j.immuni.2007.03.013
Cytomegalovirus evasion of innate immunity by subversion of the NKR-P1B:Clr-b missing-self axis
Abstract
Cytomegaloviruses are known to encode several gene products that function to subvert MHC-dependent immune recognition. Here we characterize a rat cytomegalovirus (RCMV) C-type lectin-like (RCTL) gene product with homology to the Clr ligands for the NKR-P1 receptors. RCMV infection rapidly extinguished host Clr-b expression, thereby sensitizing infected cells to killing by natural killer (NK) cells. However, the RCTL protein functioned as a decoy ligand to protect infected cells from NK killing via direct interaction with the NKR-P1B inhibitory receptor. In vivo, an RCTL mutant virus displayed diminished virulence in an NK-dependent and strain-specific manner, suggesting that host NKR-P1 polymorphisms have evolved to avert the viral decoy mechanism while maintaining Clr-b recognition to preserve self tolerance. These findings reveal a unique strategy adopted by cytomegaloviruses to evade MHC-independent self-nonself discrimination. The existence of lectin-like genes in several poxviruses suggests that this may represent a common theme for viral evasion of innate immunity.
Comment in
-
Good news, bad news for missing-self recognition by NK cells: autoimmune control but viral evasion.Immunity. 2007 May;26(5):549-51. doi: 10.1016/j.immuni.2007.05.006. Immunity. 2007. PMID: 17521583
Similar articles
-
Mouse Cytomegalovirus m153 Protein Stabilizes Expression of the Inhibitory NKR-P1B Ligand Clr-b.J Virol. 2019 Dec 12;94(1):e01220-19. doi: 10.1128/JVI.01220-19. Print 2019 Dec 12. J Virol. 2019. PMID: 31597762 Free PMC article.
-
Interferon-Dependent Induction of Clr-b during Mouse Cytomegalovirus Infection Protects Bystander Cells from Natural Killer Cells via NKR-P1B-Mediated Inhibition.J Innate Immun. 2017;9(4):343-358. doi: 10.1159/000454926. Epub 2017 Mar 14. J Innate Immun. 2017. PMID: 28288457 Free PMC article.
-
Modulation of Clr Ligand Expression and NKR-P1 Receptor Function during Murine Cytomegalovirus Infection.J Innate Immun. 2015;7(6):584-600. doi: 10.1159/000382032. Epub 2015 May 29. J Innate Immun. 2015. PMID: 26044139 Free PMC article.
-
NK cell recognition of mouse cytomegalovirus-infected cells.Curr Top Microbiol Immunol. 2006;298:183-206. doi: 10.1007/3-540-27743-9_10. Curr Top Microbiol Immunol. 2006. PMID: 16329187 Review.
-
Extending missing-self? Functional interactions between lectin-like NKrp1 receptors on NK cells with lectin-like ligands.Curr Top Microbiol Immunol. 2006;298:77-89. doi: 10.1007/3-540-27743-9_4. Curr Top Microbiol Immunol. 2006. PMID: 16323412 Review.
Cited by
-
NK cells and poxvirus infection.Front Immunol. 2013 Jan 28;4:7. doi: 10.3389/fimmu.2013.00007. eCollection 2013. Front Immunol. 2013. PMID: 23372568 Free PMC article.
-
High allelic polymorphism, moderate sequence diversity and diversifying selection for B-NK but not B-lec, the pair of lectin-like receptor genes in the chicken MHC.Immunogenetics. 2008 Aug;60(8):461-75. doi: 10.1007/s00251-008-0307-1. Epub 2008 Jun 24. Immunogenetics. 2008. PMID: 18574582
-
Natural killer cells in immunodefense against infective agents.Expert Rev Anti Infect Ther. 2008 Dec;6(6):867-85. doi: 10.1586/14787210.6.6.867. Expert Rev Anti Infect Ther. 2008. PMID: 19053900 Free PMC article. Review.
-
Comparison of the Gene Coding Contents and Other Unusual Features of the GC-Rich and AT-Rich Branch Probosciviruses.mSphere. 2016 Jun 15;1(3):e00091-16. doi: 10.1128/mSphere.00091-16. eCollection 2016 May-Jun. mSphere. 2016. PMID: 27340696 Free PMC article.
-
Selection signatures of litter size in Dazu black goats based on a whole genome sequencing mixed pools strategy.Mol Biol Rep. 2019 Oct;46(5):5517-5523. doi: 10.1007/s11033-019-04904-6. Epub 2019 Jun 7. Mol Biol Rep. 2019. PMID: 31175513
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials
