Differential effects of nucleus accumbens core, shell, or dorsal striatal inactivations on the persistence, reacquisition, or reinstatement of responding for a drug-paired conditioned reinforcer
- PMID: 17712353
- DOI: 10.1038/sj.npp.1301522
Differential effects of nucleus accumbens core, shell, or dorsal striatal inactivations on the persistence, reacquisition, or reinstatement of responding for a drug-paired conditioned reinforcer
Abstract
Drug-paired conditioned reinforcers can maintain persistent instrumental responding, thus providing a model of some aspects of long-term drug addiction. The purpose of the present study was to investigate the effects of inactivating the dorsal striatum (DStr), nucleus accumbens (NAcc) core, or NAcc shell on different types of responding, each maintained by drug-paired conditioned reinforcers. Inactivations were achieved by infusing a combination of baclofen and muscimol prior to (1) persistent responding for a drug-paired conditioned reinforcer, (2) reacquisition of this instrumental response after extinction by omission of the contingent conditioned stimulus (CS), or (3) CS (cue)-induced reinstatement of the original (and different) instrumental response that had previously delivered cocaine. Inactivation of the DStr attenuated persistent responding for a cocaine-paired conditioned reinforcer, as well as its reacquisition after extinction of this response, while the only effect of inactivation of the NAcc shell was to increase CS (cue)-induced reinstatement of the extinguished instrumental response that had previously delivered cocaine. Inactivation of the NAcc core affected all measures of responding maintained by drug-paired conditioned reinforcers. These results are discussed with reference to the neural systems involved in different aspects of responding maintained by drug-paired conditioned reinforcers.
Similar articles
-
Differential involvement of the core and shell subregions of the nucleus accumbens in conditioned cue-induced reinstatement of cocaine seeking in rats.Psychopharmacology (Berl). 2004 Nov;176(3-4):459-65. doi: 10.1007/s00213-004-1895-6. Epub 2004 May 11. Psychopharmacology (Berl). 2004. PMID: 15138757
-
Deep brain stimulation of the nucleus accumbens shell attenuates cue-induced reinstatement of both cocaine and sucrose seeking in rats.Behav Brain Res. 2015 Mar 15;281:125-30. doi: 10.1016/j.bbr.2014.12.025. Epub 2014 Dec 18. Behav Brain Res. 2015. PMID: 25529183 Free PMC article.
-
Deep brain stimulation of the nucleus accumbens shell attenuates cocaine priming-induced reinstatement of drug seeking in rats.J Neurosci. 2008 Aug 27;28(35):8735-9. doi: 10.1523/JNEUROSCI.5277-07.2008. J Neurosci. 2008. PMID: 18753374 Free PMC article.
-
Motivational views of reinforcement: implications for understanding the behavioral functions of nucleus accumbens dopamine.Behav Brain Res. 2002 Dec 2;137(1-2):3-25. doi: 10.1016/s0166-4328(02)00282-6. Behav Brain Res. 2002. PMID: 12445713 Review.
-
Dyadic social interaction inhibits cocaine-conditioned place preference and the associated activation of the accumbens corridor.Behav Pharmacol. 2015 Sep;26(6):580-94. doi: 10.1097/FBP.0000000000000167. Behav Pharmacol. 2015. PMID: 26221832 Free PMC article. Review.
Cited by
-
Extinction-dependent alterations in corticostriatal mGluR2/3 and mGluR7 receptors following chronic methamphetamine self-administration in rats.PLoS One. 2012;7(3):e34299. doi: 10.1371/journal.pone.0034299. Epub 2012 Mar 29. PLoS One. 2012. PMID: 22479593 Free PMC article.
-
Role of nucleus accumbens core but not shell in incubation of methamphetamine craving after voluntary abstinence.Neuropsychopharmacology. 2020 Jan;45(2):256-265. doi: 10.1038/s41386-019-0479-4. Epub 2019 Aug 18. Neuropsychopharmacology. 2020. PMID: 31422417 Free PMC article.
-
Differential Contributions of Nucleus Accumbens Subregions to Cue-Guided Risk/Reward Decision Making and Implementation of Conditional Rules.J Neurosci. 2018 Feb 21;38(8):1901-1914. doi: 10.1523/JNEUROSCI.3191-17.2018. Epub 2018 Jan 18. J Neurosci. 2018. PMID: 29348192 Free PMC article.
-
Acquisition of responding with a remifentanil-associated conditioned reinforcer in the rat.Psychopharmacology (Berl). 2013 Sep;229(2):235-43. doi: 10.1007/s00213-013-3102-0. Epub 2013 Apr 23. Psychopharmacology (Berl). 2013. PMID: 23609770 Free PMC article.
-
Fos expression in response to dopamine D3-preferring phenylpiperazine drugs given with and without cocaine.Synapse. 2013 Dec;67(12):847-55. doi: 10.1002/syn.21691. Epub 2013 Jul 17. Synapse. 2013. PMID: 23766142 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
