Metformin, heart failure, and lactic acidosis: is metformin absolutely contraindicated?

doi:10.1136/bmj.39255.669444.AE

Review

. 2007 Sep 8;335(7618):508-12.

doi: 10.1136/bmj.39255.669444.AE.

Metformin, heart failure, and lactic acidosis: is metformin absolutely contraindicated?

A A Tahrani¹, G I Varughese, J H Scarpello, F W F Hanna

Affiliations

PMID: 17823192
PMCID: PMC1971167
DOI: 10.1136/bmj.39255.669444.AE

Review

Metformin, heart failure, and lactic acidosis: is metformin absolutely contraindicated?

A A Tahrani et al. BMJ. 2007.

. 2007 Sep 8;335(7618):508-12.

doi: 10.1136/bmj.39255.669444.AE.

Authors

A A Tahrani¹, G I Varughese, J H Scarpello, F W F Hanna

Affiliation

¹ Department of Diabetes and Endocrinology, University Hospital of North Staffordshire, Stoke-on-Trent ST4 6QG. abdtahrani@yahoo.co.uk

PMID: 17823192
PMCID: PMC1971167
DOI: 10.1136/bmj.39255.669444.AE

Abstract

Many patients with type 2 diabetes are denied treatment with metformin because of “contraindications” such as cardiac failure, which may not be absolute contraindications

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Conflict of interest statement

Competing interests: None declared.

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References

1. UK Prospective Diabetes Study (UKPDS) Group. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet 1998;352:854-65. - PubMed
1. Glucophage. (accessed 6 July 2007).www.fda.gov/medwatch/SAFETY/2004/mar_PI/Glucophage_PI.pdf
1. Salpeter S, Greyber E, Pasternak G, Salpeter E. Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus. Cochrane Database Syst Rev 2006;(1):CD002967. - PubMed
1. Emslie-Smith AM, Boyle DI, Evans JM, Sullivan F, Morris AD. Contraindications to metformin therapy in patients with type 2 diabetes—a population-based study of adherence to prescribing guidelines. Diabet Med 2001;18:483-8. - PubMed
1. Masoudi FA, Inzucchi SE, Wang Y, Havranek EP, Foody JM, Krumholz HM. Thiazolidinediones, metformin, and outcomes in older patients with diabetes and heart failure: an observational study. Circulation 2005;111:583-90. - PubMed

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[1] UK Prospective Diabetes Study (UKPDS) Group. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet 1998;352:854-65. - PubMed

[2] UK Prospective Diabetes Study (UKPDS) Group. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet 1998;352:854-65. - PubMed

[3] Glucophage. (accessed 6 July 2007).www.fda.gov/medwatch/SAFETY/2004/mar_PI/Glucophage_PI.pdf

[4] Glucophage. (accessed 6 July 2007).www.fda.gov/medwatch/SAFETY/2004/mar_PI/Glucophage_PI.pdf

[5] Salpeter S, Greyber E, Pasternak G, Salpeter E. Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus. Cochrane Database Syst Rev 2006;(1):CD002967. - PubMed

[6] Salpeter S, Greyber E, Pasternak G, Salpeter E. Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus. Cochrane Database Syst Rev 2006;(1):CD002967. - PubMed

[7] Emslie-Smith AM, Boyle DI, Evans JM, Sullivan F, Morris AD. Contraindications to metformin therapy in patients with type 2 diabetes—a population-based study of adherence to prescribing guidelines. Diabet Med 2001;18:483-8. - PubMed

[8] Emslie-Smith AM, Boyle DI, Evans JM, Sullivan F, Morris AD. Contraindications to metformin therapy in patients with type 2 diabetes—a population-based study of adherence to prescribing guidelines. Diabet Med 2001;18:483-8. - PubMed

[9] Masoudi FA, Inzucchi SE, Wang Y, Havranek EP, Foody JM, Krumholz HM. Thiazolidinediones, metformin, and outcomes in older patients with diabetes and heart failure: an observational study. Circulation 2005;111:583-90. - PubMed

[10] Masoudi FA, Inzucchi SE, Wang Y, Havranek EP, Foody JM, Krumholz HM. Thiazolidinediones, metformin, and outcomes in older patients with diabetes and heart failure: an observational study. Circulation 2005;111:583-90. - PubMed

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Metformin, heart failure, and lactic acidosis: is metformin absolutely contraindicated?

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Metformin, heart failure, and lactic acidosis: is metformin absolutely contraindicated?

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