Review
doi: 10.1136/bmj.39255.669444.AE.
Metformin, heart failure, and lactic acidosis: is metformin absolutely contraindicated?
Affiliations
- PMID: 17823192
- PMCID: PMC1971167
- DOI: 10.1136/bmj.39255.669444.AE
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Review
Metformin, heart failure, and lactic acidosis: is metformin absolutely contraindicated?
BMJ.
.
Abstract
Many patients with type 2 diabetes are denied treatment with metformin because of “contraindications” such as cardiac failure, which may not be absolute contraindications
Conflict of interest statement
Competing interests: None declared.
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References
-
- UK Prospective Diabetes Study (UKPDS) Group. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet 1998;352:854-65. - PubMed
-
- Glucophage. (accessed 6 July 2007).www.fda.gov/medwatch/SAFETY/2004/mar_PI/Glucophage_PI.pdf
-
- Salpeter S, Greyber E, Pasternak G, Salpeter E. Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus. Cochrane Database Syst Rev 2006;(1):CD002967. - PubMed
-
- Emslie-Smith AM, Boyle DI, Evans JM, Sullivan F, Morris AD. Contraindications to metformin therapy in patients with type 2 diabetes—a population-based study of adherence to prescribing guidelines. Diabet Med 2001;18:483-8. - PubMed
-
- Masoudi FA, Inzucchi SE, Wang Y, Havranek EP, Foody JM, Krumholz HM. Thiazolidinediones, metformin, and outcomes in older patients with diabetes and heart failure: an observational study. Circulation 2005;111:583-90. - PubMed
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