Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2008 Jul;33(7):1263-76.
doi: 10.1007/s11064-007-9578-4. Epub 2008 Feb 13.

Distribution and expression of protein kinase C interactive protein (PKCI/HINT1) in mouse central nervous system (CNS)

Qing Liu  1 , Adam C Puche, Jia Bei Wang
Affiliations

Distribution and expression of protein kinase C interactive protein (PKCI/HINT1) in mouse central nervous system (CNS)

Qing Liu et al. Neurochem Res. 2008 Jul.

Abstract

Protein kinase C interactive protein (PKCI; also known as histidine triad protein, HINT1) is a small intracellular protein widely expressed in tissues from both the peripheral and CNS. Although the structure of this protein is well characterized, the functional aspect and cellular distribution of the protein remain unknown, especially in CNS. To analyze the expression pattern of PKCI/HINT1 we used antibodies against either the whole recombinant protein or a peptide epitope of PKCI/HINT1. We find widespread of PKCI/HINT1 expression in the mouse CNS by Western blot and immunostaining. Our data indicates that PKCI/HINT1 is present broadly throughout the regions of CNS with relatively high abundance in olfactory system, cerebral cortex, hippocampus and part of thalamus, hypothalamus, midbrain, pons and medulla. On the cellular level, PKCI/HINT1 immunoreactivity is primarily located in neurons and neuronal processes. This study provides the anatomical evidence for the potential roles of PKCI/HINT1 in neuronal function.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Biol Chem. 2006 Sep 15;281(37):27356-66 - PubMed
    1. Brain Res. 1994 Sep 12;656(2):245-56 - PubMed
    1. J Neurosci. 2000 Feb 1;20(3):1179-89 - PubMed
    1. Synapse. 2000 Jul;37(1):1-15 - PubMed
    1. Science. 2000 Jan 14;287(5451):273-8 - PubMed

Publication types

LinkOut - more resources

  NODES
twitter 2