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Review
. 2008 Mar;15(2):88-94.
doi: 10.1097/MOH.0b013e3282f3deaa.

Exploiting the mammalian _target of rapamycin pathway in hematologic malignancies

Jessica K Altman  1 , Leonidas C Platanias
Affiliations
Review

Exploiting the mammalian _target of rapamycin pathway in hematologic malignancies

Jessica K Altman et al. Curr Opin Hematol. 2008 Mar.

Abstract

Purpose of review: This review critically assesses recent research advances in elucidating the role of the mammalian _target of rapamycin pathway in the pathogenesis of hematologic malignancies and the potential of _targeting this signaling pathway to treat such malignancies.

Recent findings: Mammalian _target of rapamycin is a highly conserved serine/threonine protein kinase that controls initiation of mRNA translation, cell cycle progression, and cellular proliferation. Recent dramatic advances in research into cellular signaling by mammalian _target of rapamycin and its effectors, and better understanding of aberrant activation of mammalian _target of rapamycin pathways in hematologic malignancies have stimulated considerable interest in the clinical development of inhibitors that _target this pathway. Numerous clinical trials using mammalian _target of rapamycin inhibitors are ongoing in various hematologic malignancies. Such trials are direct extensions of preclinical work establishing that inhibition of this pathway blocks cell proliferation and/or induces apoptotic cell death, both in vitro and in vivo.

Summary: The role of the mammalian _target of rapamycin pathway in hematologic malignancies is of considerable interest with major clinical/translational relevance. Here, our understanding of the functional roles of the mammalian _target of rapamycin pathway and its deregulation in hematologic malignancies are summarized and resulting clinical/translational efforts discussed.

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