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Review
. 2008 May;67(5):423-30.
doi: 10.1111/j.1365-3083.2008.02089.x. Epub 2008 Mar 17.

Complement component c1q and anti-c1q antibodies in theory and in clinical practice

E Potlukova  1 , P Kralikova
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Free article
Review

Complement component c1q and anti-c1q antibodies in theory and in clinical practice

E Potlukova et al. Scand J Immunol. 2008 May.
Free article

Abstract

The complement system is a major part of the innate immunity. The first component of the classical pathway of complement activation, C1q, plays a crucial role in the clearance of immune complexes and apoptotic bodies from the organism. Autoantibodies against C1q (anti-C1q) have been found in a number of autoimmune and infectious diseases. They have been best described in patients with systemic lupus erythematosus, where they are thought to play a pathogenic role in lupus nephritis (LN). Their high negative predictive value for the occurrence of active proliferative LN, as well as their possible ability to indicate a renal flare as soon as 6 months in advance, have rendered anti-C1q antibodies a novel non-invasive tool in the detection of active LN.

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