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. 2008 Apr;106(4):667-70.
doi: 10.1254/jphs.08004sc. Epub 2008 Apr 9.

Evidence for separate involvement of different mu-opioid receptor subtypes in itch and analgesia induced by supraspinal action of opioids

Tsugunobu Andoh  1 , Yuichi Yageta, Mitsuhiro Konno, Tomomi Yamaguchi-Miyamoto, Hiroki Takahata, Hiroshi Nojima, Hideo Nemoto, Yasushi Kuraishi
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Free article

Evidence for separate involvement of different mu-opioid receptor subtypes in itch and analgesia induced by supraspinal action of opioids

Tsugunobu Andoh et al. J Pharmacol Sci. 2008 Apr.
Free article

Abstract

The common adverse effect of centrally-injected mu-opioid receptor (mu-OR) agonists is pruritus. This study was conducted using mice to examine whether different subtypes of mu-OR would be responsible for pruritus and analgesia. Intracisternal injections of morphine and morphine-6beta-glucronide (M6G), but not M3G, produced an antinociceptive effect. Morphine, but neither M6G nor M3G, induced facial scratching, a pruritus-related response. Facial scratching following morphine was not affected by the mu(1)-OR antagonist naloxonazine at doses that inhibited the antinociceptive effects. The results suggest that different subtype and/or splice variants of mu-OR are separately involved in pruritus and antinociception of opioids.

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