Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2008 Sep;115(9):1251-5.
doi: 10.1007/s00702-008-0071-2. Epub 2008 Jul 16.

Downhill training upregulates mice hippocampal and striatal brain-derived neurotrophic factor levels

Aderbal S Aguiar Jr  1 , Ana E Speck, Rui D S Prediger, Flávio Kapczinski, Ricardo A Pinho
Affiliations

Downhill training upregulates mice hippocampal and striatal brain-derived neurotrophic factor levels

Aderbal S Aguiar Jr et al. J Neural Transm (Vienna). 2008 Sep.

Abstract

This study examined the effects of downhill treadmill exercise on brain-derived neurotrophic factor (BDNF) protein on the hippocampus and striatum of mice. Twenty-four adult mice were assigned to three groups: non-runners control, level or downhill (16 degrees decline) running exercise. The exercise schedule consisted of progressive treadmill running for 5 days week(-1) over 8 weeks. Blood lactate levels classified exercise intensity as moderate to high. Both training types increased citrate synthase activity of the soleus muscle when compared to untrained controls. While level running increased BDNF levels selectively in the hippocampus (68.5%), the eccentric running resulted in a pronounced BDNF increase in both the hippocampus (137.0%) and the striatum (49.9%). Further studies will specify whether the observed alterations in BDNF are due to downhill-induced upregulation or complex learning-induced mechanisms that influence BDNF levels in these brain regions.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Brain Res. 2007 May 30;1150:207-16 - PubMed
    1. Biochem J. 1976 Mar 15;154(3):689-700 - PubMed
    1. Brain Res. 1996 Jul 8;726(1-2):49-56 - PubMed
    1. J Endocrinol Invest. 2004 Jun;27(6):603-12 - PubMed
    1. Brain Behav Immun. 2005 Sep;19(5):445-52 - PubMed

Publication types

LinkOut - more resources

  NODES
twitter 2