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Multicenter Study
. 2009 Aug;20(8):1401-6.
doi: 10.1007/s00198-008-0810-0. Epub 2008 Dec 13.

Bone mass and structure in adolescents with type 1 diabetes compared to healthy peers

M T Saha  1 , H Sievänen, M K Salo, S Tulokas, H H Saha
Affiliations
Multicenter Study

Bone mass and structure in adolescents with type 1 diabetes compared to healthy peers

M T Saha et al. Osteoporos Int. 2009 Aug.

Abstract

Summary: We measured bone mass and structure using pQCT and DXA in adolescents with Type 1 diabetes and compared the results with those of healthy peers. Our results showed that diabetes is associated with reduced bone mass and smaller bones. The diabetes-associated deficits seemed to concern male adolescents more than females.

Introduction: The aim of this study was to compare bone mass and structure between adolescents with type 1 diabetes and their healthy peers.

Methods: Peripheral quantitative computed tomography (pQCT) at radius and tibia, and dual-energy X-ray absorptiometry (DXA) at lumbar spine and proximal femur were performed for 48 adolescents, 26 girls and 22 boys, with type 1 diabetes, and for healthy peers matched for age, sex, body height and weight, and pubertal maturity.

Results: Diabetes was associated with reduced bone mineral content (BMC) and smaller bone cross-sectional size. Diabetic boys seemed to be more affected than diabetic girls. Among the boys, the mean deficit in BMC of all measured skeletal sites was more than 10%, while among the girls it was less than 5%.

Conclusion: In conclusion, type 1 diabetes is associated with reduced BMC and appears to affect bone cross-sectional size and cortical rigidity. The diabetes-related skeletal deficits seemed to concern male adolescents more than females. Whether diabetes-related deficits would contribute to an increased risk of fractures in adulthood or later in life remains to be confirmed.

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