Review
doi: 10.1016/j.semcancer.2008.11.009.
Epub 2008 Dec 9.
Regulation of cancer cell metabolism by hypoxia-inducible factor 1
Affiliations
- PMID: 19114105
- DOI: 10.1016/j.semcancer.2008.11.009
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Review
Regulation of cancer cell metabolism by hypoxia-inducible factor 1
Semin Cancer Biol.
2009 Feb.
Abstract
The induction of hypoxia-inducible factor 1 (HIF-1) activity, either as a result of intratumoral hypoxia or loss-of-function mutations in the VHL gene, leads to a dramatic reprogramming of cancer cell metabolism involving increased glucose transport into the cell, increased conversion of glucose to pyruvate, and a concomitant decrease in mitochondrial metabolism and mitochondrial mass. Blocking these adaptive metabolic responses to hypoxia leads to cell death due to toxic levels of reactive oxygen species. _targeting HIF-1 or metabolic enzymes encoded by HIF-1 _target genes may represent a novel therapeutic approach to cancer.
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