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Comparative Study
. 2008 Oct;7(7):761-9.
doi: 10.1111/j.1601-183x.2008.00415.x.

Identification of quantitative trait loci for locomotor activation and anxiety using closely related inbred strains

J S Bailey  1 , L Grabowski-Boase, B M Steffy, T Wiltshire, G A Churchill, L M Tarantino
Affiliations
Comparative Study

Identification of quantitative trait loci for locomotor activation and anxiety using closely related inbred strains

J S Bailey et al. Genes Brain Behav. 2008 Oct.

Abstract

We carried out a quantitative trait loci (QTL) mapping experiment in two phenotypically similar inbred mouse strains, C57BL/6J and C58/J, using the open-field assay, a well-established model of anxiety-related behavior in rodents. This intercross was initially carried out as a control cross for an ethylnitrosurea mutagenesis mapping study. Surprisingly, although open-field behavior is similar in the two strains, we identified significant QTL in their F2 progeny. Marker regression identified a locus on Chr 8 having associations with multiple open-field measures and a significant interaction between loci on Chr 13 and 17. Together, the Chr 8 locus and the interaction effect form the core set of QTL controlling these behaviors with additional loci on Chr 1 and 6 present in a subset of the behaviors.

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Figures

Figure 1
Figure 1
Genome-wide scans for all behaviors. Dashed line indicates corrected genomewide significance threshold of LOD 3.2 at P=0.05. Dotted line indicates suggestive threshold of LOD 2.1 at P=0.63.
Figure 2
Figure 2
Interaction effects for Chr 13 and Chr 17 loci. A) Main effect of Chr 17 QTL at 45.986Mb for activity related traits and interaction with Chr 13 locus and B) main effect of Chr 13 QTL at 67.446Mb for anxiety trait and interaction with Chr 17 locus. Error bars are standard error of the mean.
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