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Multicenter Study
. 2009 Aug;15(7):490-4.
doi: 10.1016/j.parkreldis.2008.12.005. Epub 2009 Jan 11.

Prevalence of smell loss in Parkinson's disease--a multicenter study

A Haehner  1 , S Boesveldt, H W Berendse, A Mackay-Sim, J Fleischmann, P A Silburn, A N Johnston, G D Mellick, B Herting, H Reichmann, T Hummel
Affiliations
Multicenter Study

Prevalence of smell loss in Parkinson's disease--a multicenter study

A Haehner et al. Parkinsonism Relat Disord. 2009 Aug.

Abstract

Previous data on the prevalence of olfactory dysfunction in Parkinson's disease (PD) range from 45% to 90%. The present multicenter study aimed to provide data on the prevalence of smell loss in a large sample of PD patients from three independent populations. Olfactory sensitivity was tested in 400 patients from Australia, Germany, and The Netherlands by means of a psychophysical olfactory test, the "Sniffin' Sticks", which is comprised of 3 subtests of olfactory function. Out of the total number of patients 45.0% presented as functionally anosmic, 51.7% were hyposmic, whereas only 3.3% were normosmic. This indicates that 96.7% of PD patients present with significant olfactory loss when compared to young normosmic subjects. This figure falls to 74.5%, however, when adjusted to age-related norms. Thus, olfactory dysfunction should be considered as a reliable marker of the disease.

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