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. 2009 Mar;16(3):430-2.
doi: 10.1128/CVI.00480-08. Epub 2009 Jan 14.

Efficacy of a genetically engineered Candida albicans tet-NRG1 strain as an experimental live attenuated vaccine against hematogenously disseminated candidiasis

Stephen P Saville  1 , Anna L Lazzell, Ashok K Chaturvedi, Carlos Monteagudo, Jose L Lopez-Ribot
Affiliations

Efficacy of a genetically engineered Candida albicans tet-NRG1 strain as an experimental live attenuated vaccine against hematogenously disseminated candidiasis

Stephen P Saville et al. Clin Vaccine Immunol. 2009 Mar.

Abstract

We report on the efficacy of the genetically engineered Candida albicans tet-NRG1 strain as an experimental live, attenuated vaccine against disseminated candidiasis in both immunocompetent and immunodeficient mice mostly dependent on T-cell immunity. This experimental vaccination model may represent an important tool to unravel the mechanisms of protective immunity during candidiasis.

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Figures

FIG. 1.
FIG. 1.
Survival curves for C. albicans tet-NRG1-vaccinated (open circles) and nonvaccinated control (open squares) groups of BALB/c mice after subsequent challenge with a lethal dose of the fully virulent C. albicans CAF-2 strain. Results are displayed as percent survival from the time of the secondary challenge. P = 0.0031.
FIG. 2.
FIG. 2.
Survival curves for different groups of immunodeficient mice vaccinated or not vaccinated with the C. albicans tet-NRG1 strain SSY50-B after subsequent challenge with a lethal dose of the fully virulent C. albicans CAF-2 strain. (A) Survival of vaccinated (closed triangles) and unvaccinated (closed circles) B-cell-deficient mice. P = 0.0031. (B) Survival of vaccinated (closed triangles) and unvaccinated (closed circles) DBA/2N mice. P = 0.0027. (C) Survival of vaccinated (closed triangles) and unvaccinated (closed circles) nude mice. P = 0.0522. The experimental details are the same as for the experiments using the BALB/c mice depicted in Fig. 1. The results are again displayed as percent survival from the time of the secondary challenge. Results from experiments with immunocompetent BALB/c mice (vaccinated, open circles; nonvaccinated, open squares) are overlaid in each panel for comparison.
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