Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2009 May;10(5):295-304.
doi: 10.1038/nrg2540.

Linking DNA methylation and histone modification: patterns and paradigms

Howard Cedar  1 , Yehudit Bergman
Affiliations
Review

Linking DNA methylation and histone modification: patterns and paradigms

Howard Cedar et al. Nat Rev Genet. 2009 May.

Abstract

Both DNA methylation and histone modification are involved in establishing patterns of gene repression during development. Certain forms of histone methylation cause local formation of heterochromatin, which is readily reversible, whereas DNA methylation leads to stable long-term repression. It has recently become apparent that DNA methylation and histone modification pathways can be dependent on one another, and that this crosstalk can be mediated by biochemical interactions between SET domain histone methyltransferases and DNA methyltransferases. Relationships between DNA methylation and histone modification have implications for understanding normal development as well as somatic cell reprogramming and tumorigenesis.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Curr Opin Cell Biol. 2008 Jun;20(3):316-25 - PubMed
    1. Nature. 1991 May 16;351(6323):239-41 - PubMed
    1. Nat Cell Biol. 2004 Aug;6(8):784-91 - PubMed
    1. EMBO J. 2008 Oct 22;27(20):2691-701 - PubMed
    1. Science. 2008 Dec 12;322(5908):1717-20 - PubMed

Publication types

LinkOut - more resources

  NODES
Association 1
chat 1
twitter 2