Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2009 Jun;52(6):1040-7.
doi: 10.1007/s00125-009-1338-3. Epub 2009 Mar 27.

Association of C-reactive protein with type 2 diabetes: prospective analysis and meta-analysis

C C Lee  1 , A I Adler, M S Sandhu, S J Sharp, N G Forouhi, S Erqou, R Luben, S Bingham, K T Khaw, N J Wareham
Affiliations
Meta-Analysis

Association of C-reactive protein with type 2 diabetes: prospective analysis and meta-analysis

C C Lee et al. Diabetologia. 2009 Jun.

Abstract

Aims/hypothesis: We examined the association between serum C-reactive protein (CRP) and incident diabetes in a prospective study, and added these data to a literature-based meta-analysis to explore potential sources of heterogeneity between studies.

Methods: We analysed a case-control study nested within the European Prospective Investigation of Cancer (EPIC)-Norfolk cohort, including 293 incident diabetes cases and 708 controls. We combined 16 published studies on CRP and incident diabetes in a random-effect meta-analysis.

Results: In the EPIC-Norfolk cohort, serum CRP was associated with a higher risk of diabetes after adjusting for age, sex, BMI, family history of diabetes, smoking and physical activity (OR 1.49, comparing the extreme thirds of CRP distribution [95% CI 1.03-2.15], p = 0.03). However, the association was completely attenuated after further adjustment for WHR, serum gamma-glutamyltransferase and serum adiponectin (OR 1.00; 95% CI 0.66-1.51, p = 1.0). In a meta-analysis of 16 published studies with 3,920 incident diabetes cases and 24,914 controls, the RR was 1.72 (95% CI 1.54-1.92), comparing the extreme thirds of CRP distribution, with substantial heterogeneity between studies (I (2) = 52.8%, p = 0.007).

Conclusions/interpretation: Initial evidence of association between CRP and incident diabetes was confounded by central adiposity, markers of liver dysfunction and adiponectin in the primary analysis. Despite an overall positive association in the meta-analysis, considerable heterogeneity existed between studies. The degree of adjustment for central adiposity and baseline glycaemia explained some of this heterogeneity and suggests that CRP may not be an independent risk factor for type 2 diabetes.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. World J Gastroenterol. 2004 Apr 1;10(7):1052-5 - PubMed
    1. Diabetes. 2002 May;51(5):1596-600 - PubMed
    1. Diabetes Care. 2005 Jul;28(7):1757-62 - PubMed
    1. J Clin Endocrinol Metab. 2004 Nov;89(11):5410-4 - PubMed
    1. Diabetes. 2004 Mar;53(3):693-700 - PubMed

Publication types

Substances

  NODES
Association 8
twitter 2