Dermatomyositis and malignancy: a retrospective study of 115 cases
- PMID: 19499841
Dermatomyositis and malignancy: a retrospective study of 115 cases
Abstract
Aim of this study was to identify the association between dermatomyositis and malignancy in China.
Methods: We retrospectively analyzed the clinical data of 115 cases of dermatomyositis associated with malignancy.
Results: From 1974 to 2008, there were 678 cases of dermatomyositis collected from the Second Affiliated Hospital, Sun Yat-Sen University, China. Among them, 115 cases (17.0%) were associated with malignancy. 7.4% (22/297) of patients under 40 years old were diagnosed with malignant tumor, while 24.4% (93/381) of patients aged 40 years or above were associated with malignancy. Malignancy preceded dermatomyositis in 14 cases. Dermatomyositis and malignancy were diagnosed at the same time in 22 patients. Another 79 patients were found to have cancer within 3 years after the dermatomyositis was diagnosed. Among them, cancer was detected in 66 patients in the first year, 11 patients in the second year and only 2 patients in the third year. Nasopharyngeal cancer made up 51.3% (59/115) of the associated malignancies, while lung cancer accounted for 17.4% (20/115). Other malignancies associated with dermatomyositis included liver cancer, ovarian cancer, cervical lymph node metastases of unknown origin, cholangial cancer, esophageal cancer, colon cancer, laryngeal cancer, renal cancer, tongue cancer and lymphoma.
Conclusions: Dermatomyositis associated with malignancy was more common in patients aged 40 years or above. Malignancy was often detected within the first year after the onset of dermatomyositis. The most common malignancy associated with dermatomyositis was nasopharyngeal cancer, followed by lung cancer in Guangdong, China.
Similar articles
-
Incidence and predictive factors for malignancies with dermatomyositis: a cohort from southern China.Clin Exp Rheumatol. 2014 Sep-Oct;32(5):615-21. Epub 2014 Jul 28. Clin Exp Rheumatol. 2014. PMID: 25068842
-
Dermatomyositis and malignancy. A multicenter cooperative study.Dermatologica. 1990;180(4):212-6. Dermatologica. 1990. PMID: 2192925 Clinical Trial.
-
Malignancies associated with dermatomyositis and polymyositis in Taiwan: a nationwide population-based study.Br J Dermatol. 2009 Oct;161(4):854-60. doi: 10.1111/j.1365-2133.2009.09274.x. Epub 2009 Apr 30. Br J Dermatol. 2009. PMID: 19558555
-
[Prognostic factors and predictive signs of malignancy in adult dermatomyositis].Ann Dermatol Venereol. 1996;123(11):722-6. Ann Dermatol Venereol. 1996. PMID: 9636749 Review. French.
-
Paraneoplastic vasculitis in patients with solid tumors: report of 15 cases.J Rheumatol. 2008 Feb;35(2):294-304. Epub 2007 Dec 15. J Rheumatol. 2008. PMID: 18085729 Review.
Cited by
-
Polymyositis and dermatomyositis as a risk of developing cancer.Reumatologia. 2015;53(2):101-5. doi: 10.5114/reum.2015.51510. Epub 2015 May 18. Reumatologia. 2015. PMID: 27407235 Free PMC article. Review.
-
Ground-glass opacity heralding invasive lung adenocarcinoma with prodromal dermatomyositis: a case report.J Cardiothorac Surg. 2018 Feb 7;13(1):20. doi: 10.1186/s13019-018-0705-x. J Cardiothorac Surg. 2018. PMID: 29415746 Free PMC article.
-
Prevalence of Nasopharyngeal Carcinoma in Patients with Dermatomyositis: A Systematic Review and Meta-Analysis.Cancers (Basel). 2021 Apr 14;13(8):1886. doi: 10.3390/cancers13081886. Cancers (Basel). 2021. PMID: 33919987 Free PMC article. Review.
-
Paraneoplastic syndromes in lung cancer and their management.Ann Transl Med. 2019 Aug;7(15):359. doi: 10.21037/atm.2019.04.86. Ann Transl Med. 2019. PMID: 31516905 Free PMC article. Review.
-
Lung cancer and interstitial lung diseases: a systematic review.Pulm Med. 2012;2012:315918. doi: 10.1155/2012/315918. Epub 2012 Jul 29. Pulm Med. 2012. PMID: 22900168 Free PMC article.