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Review
. 2009 Oct;9(10):714-23.
doi: 10.1038/nrc2716. Epub 2009 Sep 4.

Tumour suppression by p53: a role for the DNA damage response?

David W Meek  1
Affiliations
Review

Tumour suppression by p53: a role for the DNA damage response?

David W Meek. Nat Rev Cancer. 2009 Oct.

Abstract

Loss of p53 function occurs during the development of most, if not all, tumour types. This paves the way for genomic instability, tumour-associated changes in metabolism, insensitivity to apoptotic signals, invasiveness and motility. However, the nature of the causal link between early tumorigenic events and the induction of the p53-mediated checkpoints that constitute a barrier to tumour progression remains uncertain. This Review considers the role of the DNA damage response, which is activated during the early stages of tumour development, in mobilizing the tumour suppression function of p53. The relationship between these events and oncogene-induced p53 activation through the ARF pathway is also discussed.

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References

    1. J Mol Med (Berl). 2007 Nov;85(11):1175-86 - PubMed
    1. Mol Cell Biol. 2002 Jan;22(1):370-7 - PubMed
    1. Proc Natl Acad Sci U S A. 1996 May 14;93(10):4827-32 - PubMed
    1. Nature. 1992 Mar 19;356(6366):215-21 - PubMed
    1. Science. 2006 Jun 16;312(5780):1650-3 - PubMed

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