Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Oct;16(10):1086-93.
doi: 10.1038/nsmb.1669. Epub 2009 Sep 27.

The execution of the transcriptional axis mutant p53, E2F1 and ID4 promotes tumor neo-angiogenesis

Giulia Fontemaggi  1 , Stefania Dell'Orso, Daniela Trisciuoglio, Tal Shay, Elisa Melucci, Francesco Fazi, Irene Terrenato, Marcella Mottolese, Paola Muti, Eytan Domany, Donatella Del Bufalo, Sabrina Strano, Giovanni Blandino
Affiliations

The execution of the transcriptional axis mutant p53, E2F1 and ID4 promotes tumor neo-angiogenesis

Giulia Fontemaggi et al. Nat Struct Mol Biol. 2009 Oct.

Abstract

ID4 (inhibitor of DNA binding 4) is a member of a family of proteins that function as dominant-negative regulators of basic helix-loop-helix transcription factors. Growing evidence links ID proteins to cell proliferation, differentiation and tumorigenesis. Here we identify ID4 as a transcriptional _target of gain-of-function p53 mutants R175H, R273H and R280K. Depletion of mutant p53 protein severely impairs ID4 expression in proliferating tumor cells. The protein complex mutant p53-E2F1 assembles on specific regions of the ID4 promoter and positively controls ID4 expression. The ID4 protein binds to and stabilizes mRNAs encoding pro-angiogenic factors IL8 and GRO-alpha. This results in the increase of the angiogenic potential of cancer cells expressing mutant p53. These findings highlight the transcriptional axis mutant p53, E2F1 and ID4 as a still undefined molecular mechanism contributing to tumor neo-angiogenesis.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Nat Rev Cancer. 2005 Aug;5(8):603-14 - PubMed
    1. Head Neck. 2007 May;29(5):488-96 - PubMed
    1. J Cell Physiol. 2002 Jan;190(1):21-8 - PubMed
    1. EMBO J. 2005 Aug 3;24(15):2768-82 - PubMed
    1. Semin Cell Dev Biol. 2005 Feb;16(1):59-67 - PubMed

Publication types

MeSH terms

LinkOut - more resources

  NODES
twitter 2